Hi, I have recently been diagnosed with PBC, I have found the information I have found here really useful and reasuring. I was prescribed urso and deloxetine but had to stop taking the deloxetine due to horrendous side effects. I have been getting awful nausea and stomach/back pain for a week, this tends to be in the evening around 7 pm. Does anyone else have this? Also terrible joint pain mainly in the morning. No itching yet.