I am very interested in research or lack thereof regarding PBC and Hormone levels. Since it effects mostly women that would be a very telling causal effect. My additional diagnosis includes Premature Ovarian Failure/early onset menopause and Hypo thyroid. If this is all hormone related we should be working harder to screen and treat women for hormone related deficiencies rather than wait for these catastrophic failures of our systems.... I know that there are environmental issues as well.