Just pondering at 3.10am in the morning when not sleeping! Having looked on the Liver Trust website and the details related to a funded research programme, this focused on a certain area which looked at whether the condition may be related to a virus which could have been dormant and then reactivated later in life. I am wondering if anyone with PBC has had a serious condition in their past which could have produced such a virus. I am thinking (from my experience) when I had a serious bout of Salmonella food poisoning when I was in my late 20's (I'm 57 now) and was in an isolation hospital for 6 weeks. My digestion was never the same after that. I have since had my gallbladder removed and then diagnosed a year after with PBC I know other studies are looking at the genetic side of the source, but I do know a few people with PBC who have also had a traumatic digestive episode in their younger lives. Anyway, makes you think, doesn't it?