Hi everyone, for past 20+ years I struggled with fatigue,gastric issues pins and nèedles in hands and feet and electric shock sensations down my right side.all started after 4 hour op,hysterectomy where nitrous oxide was given to me . Usual story, it's stress, all in your head. 3 years ago I was started on 3 monthly b12 injections as I had a level of 167. No loading doses. It has taken a long time but the injections really help,I now have 10 weekly and occasional SI. I am on Rampiril for BP. Past month BP high, headaches, nausea and fatigue. Then I had my jab at the surgery and within a few days started to feel better and BP started to come down. Due to do 24hour monitor this week. Pharmacist rang today and suggested a new b12 drug that apparently has a longer lasting effect. I questioned this saying, given I had gastric problems it is probably an absorption issue and was loathe to give it a try preffering to continue with injections. Has anyone heard of this new drug. Sony I can't remember name of drug and apologies for long winded post. Xx
New oral b12 drug: Hi everyone, for... - Pernicious Anaemi...
New oral b12 drug
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No I've not heard of it .Interested though when you find out the name of it .
Definitely stay with your injections 💉
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I doubt there is a new drug more that someone has licenced a high dose oral product - there has been talk of it for some time. It works for some people but not for everyone. Some studies in Canada showed large numbers of people (60% ish if memory serves) preferring high dose oral as more convenient than periodic injections. That was quite a large scale study
Whether or not it works seems to be totally independent of what the cause of B12 absorption is from other studies that I have seen but they have all been relatively small scale studies.
Thank you Gambit. I'm still not sure how oral b12 will be effective for absorption issues.. will ask for evidence based information.
it works using a different mechanism called passive absorption - on average this absorbs 1% of the B12 that passes through the gut. However, as always an average is an average and people vary - for some people it just doesn't seem to work at all,
Do not be surprised if this is quoted:
Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study.
europepmc.org/article/MED/3...
Though lack of access to the full paper leaves me very much unconvinced.