New oral b12 drug

[Mrsmr]

Hi everyone, for past 20+ years I struggled with fatigue,gastric issues pins and nèedles in hands and feet and electric shock sensations down my right side.all started after 4 hour op,hysterectomy where nitrous oxide was given to me . Usual story, it's stress, all in your head. 3 years ago I was started on 3 monthly b12 injections as I had a level of 167. No loading doses. It has taken a long time but the injections really help,I now have 10 weekly and occasional SI. I am on Rampiril for BP. Past month BP high, headaches, nausea and fatigue. Then I had my jab at the surgery and within a few days started to feel better and BP started to come down. Due to do 24hour monitor this week. Pharmacist rang today and suggested a new b12 drug that apparently has a longer lasting effect. I questioned this saying, given I had gastric problems it is probably an absorption issue and was loathe to give it a try preffering to continue with injections. Has anyone heard of this new drug. Sony I can't remember name of drug and apologies for long winded post. Xx

[Nackapan]

No I've not heard of it .Interested though when you find out the name of it .

Definitely stay with your injections 💉

[Mrsmr in reply to Nackapan]

Thanks for your reply Nackapan. I intend to ask for the written evidence. I will let you know the name of the drug when I next speak to the pharmacist.

[Gambit62 Administrator]

I doubt there is a new drug more that someone has licenced a high dose oral product - there has been talk of it for some time. It works for some people but not for everyone. Some studies in Canada showed large numbers of people (60% ish if memory serves) preferring high dose oral as more convenient than periodic injections. That was quite a large scale study

Whether or not it works seems to be totally independent of what the cause of B12 absorption is from other studies that I have seen but they have all been relatively small scale studies.

[Mrsmr in reply to Gambit62]

Thank you Gambit. I'm still not sure how oral b12 will be effective for absorption issues.. will ask for evidence based information.

[Gambit62 Administrator in reply to Mrsmr]

it works using a different mechanism called passive absorption - on average this absorbs 1% of the B12 that passes through the gut. However, as always an average is an average and people vary - for some people it just doesn't seem to work at all,

[helvella in reply to Mrsmr]

Do not be surprised if this is quoted:

Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study.

europepmc.org/article/MED/3...

Though lack of access to the full paper leaves me very much unconvinced.

[Mrsmr in reply to helvella]

Many thanks. A small study which leaves me unconvinced like you. X