30+- days of Thiamine trial. It has been life changing. (At the dosage I administered) See Elliot Overton for result based research not unproved projections utilizing conjecture about the meaning of scientific study.
I used a different method to deal with the healing too quickly. Rather than adjust the amounts I simply adjusted the number of times that I administered per day. That allowed me to regulate the changes. Even positive changes are a strain on my body.
I did another trial of increasing the concentration and keeping the amount per day the same. I did this with hydroxocobalamin, one of the three forms I inject and was surprised to find it was more effective even though it was a minor % change.
I have accepted that when I improve my supplementation that there is a period of downturn. I am working with the assumption that is only the result of my not supplementing effectively and am trying to figure that out.
The downturn has become very specific as I improve my understanding and therefore supplementation. I might notice an effect on my Vagus nerve (teeth ache), a bit of brain haze at times, fatigue at times which is not tiredness. These effects are minor and have a shorter duration as I improve my supplementation. I also experience a uptick at the beginning of a positive change.
I started a trial of increasing my B12 injections by 50%. I chose to approach the effects differently. I surmised that the uptick was from my history of life long B12 deficiency and the uptick was me feeling that I was improving and that I could now go for it and recover as I go along which I have done my whole life until three ½ years ago. I chose to not react to the uptick and give my body more energy to heal.
As expected the first day was fine and I had to work on not doing more. The second day was rough and this is the third day and I seem to be coming around. It takes time, not years or months.
I have come to understand the downturn feels now not like flu symptoms rather hay fever symptoms. What I have called my stuffy head. I have added Betine and from past experience know that may help.
Emotionally it is a challenge to keep changing my supplementation and not call it good enough/works because it is summer and there is lots of fun to be had. I am going with rational work now will mean a better future.
It is also emotionally difficult to make positive changes that at first seem like what used to happen throughout my life as symptoms ebbed until they waned 3 + years ago. Easier now I have improved my supplementation and the downturn is days.
I noticed that the number of conditions that are a misdiagnosis and it is really B12 indicates they suck at those diagnosis also. It seems like with any autoimmune disease is accepted as all you can do it bla bla bla. Pay well.