Peripheral neuropathy

[tomdickharry]

Just researching vitamin K2 and found this.....

Peripheral neuropathy (PN)

Diabetic peripheral neuropathy is a frequent and severe

complication of diabetes. A recent study aimed to evaluate

factors associated with sensitive diabetic neuropathy in Type

2 Diabetes, and, in particular, dephospho-uncarboxylated

Matrix-gla-protein (dp-ucMGP), the inactive form of MGP.

Peripheral neuropathy was present in 15.7% of the patients and

was significantly associated with dp-ucMGP levels. Since MGP

is expressed in several components of the nervous system and

is involved in some neurological disease, it is likely to play a

role in peripheral nervous system homeostasis. Further studies

are needed to determine if dp-ucMGP may be used as a

biomarker of sensitive neuropathy.29

Another study with the objective to assess the efficacy,

tolerability and safety of vitamin K2 as MK7 in patients with

peripheral neuropathy was conducted in 100 participants

presenting with PN and suffering from either Vitamin B12

Deficiency (VBD, megaloblastic anaemia) or Type 2 Diabetes

Mellitus (T2DM). For the first time, in larger sample size, it

has been shown that K2 as MK7 at a dose of 100 mcg twice a

day for 8 weeks has a therapeutic activity for the symptoms

of PN in VBD and T2DM. It also helps in relieving the

associated symptoms of PN such as cramps, burning pain,

weakness, and fatigue. The reduction in symptoms was

persistent even after the discontinuation of MK7. Vitamin K2

as MK7 was also well tolerated by all patients. Thus, it proves

that vitamin K2 as MK7 offers a confirming therapeutic effect

in PN due to VBD or T2DM. Further, a multicentric

placebo-controlled randomized double-blind trial can clearly

establish the effect of vitamin K2 as MK7, also in case of

residual neuropathy.30

[WIZARD6787]

Thank you for that!!! very helpful. Great the work even lists an amount and duration. Progress?

[Technoid]

Would caution against any conclusions from this research. Study sponsorship is from Synergia Life Sciences, "a leading developer and manufacturer of vitamin K2 and probiotics."

Paper is here : journals.sagepub.com/doi/pd...

The vitamin K2 research space has a lot of issues related to funding of research which give pause before drawing any conclusions until independently verified research happens.

[tomdickharry in reply to Technoid]

Thanks, it was just something I read.

At that level it can't do any harm, though. My study was about calcium deposits in arteries.

[Cherylclaire Forum Support in reply to tomdickharry]

Anything you find out about arterial calcium deposits, tomdickharry , let me know !

[tomdickharry in reply to Cherylclaire]

All I know so far is that vitamin D3 is needed to produce cholesterol from sunlight and to absorb calcium. Then K2 MK7 (preferred to MK4) is required to transport calcium from blood into bones.

Without K2 calcium stays in blood vessels and tissues. In blood vessels it can combine with cholesterol to form plaque. In tissues it can lead to calcification of organs, especially the pineal gland. K2 and D3 are both fat soluble and remain in circulation for days. K2 does have an effect on blood clotting but I believe in normal doses it's ok. K1 from vegetables is the vitamin K form most concerned with clotting and is eliminated within a couple of hours.

That's all so far.

[Cherylclaire Forum Support in reply to tomdickharry]

Thanks.

I tried to discuss cholesterol levels, calcification of the coronary arteries, osteoporosis and D3 and K2 with GPs but never got much in response beyond "Take the statins" !

[tomdickharry in reply to Cherylclaire]

Yes, I had the same problem. Even though my cholesterol ratio was only very slightly out they demanded that I take statins. Refused of course. Similarly with blood sugar, I refused to be labelled 'diabetic'.

I don't know what other problems you might have, but pernicious anaemia and B12 deficiency, plus treatment for it, can apparently affect HbA1c and get you labelled pre-diabetic.

[Cherylclaire Forum Support in reply to tomdickharry]

I refused statins the first time they were offered to me - for ventricular ectopics, which eventually went without any medication - but the second time, I got concerned as a routine lung health check revealed calcification of coronary arteries and GP got cholesterol checked. Since both my mum and dad had heart problems (several heart attacks etc) I decided that I should take statins. It has now been 3 months, so I'm due a blood test for cholesterol check.

I'm putting it off a bit - too near Christmas still !

[tomdickharry in reply to Cherylclaire]

Good luck with your tests. Over time K2 should help clear your arteries. I can only speak for myself, of course, but would never take statins. I know too many people, family included, who've suffered severe side effects despite following medical advice. Me? I eat butter, cook in lard, love bacon, etc. I take my vitamins and anti-oxidants, monitor my blood pressure and all other reasonable precautions. I have other problems that limit my mobility and therefore my exercise; would love to get out more but can't. Once more, good luck with tests.

[Technoid in reply to Cherylclaire]

might be useful for you Cherylclaire m.youtube.com/watch?v=zm4J4...(Not working as expected?)

[Hectorsmum2 in reply to Technoid]

it might be biased but no more so than drug company research into the drugs they peddle. Yet accepted as gospel by doctors.

[qwertystar]

that’s great! I’m already taking K2 MK7 with vitamin D

[OldmanD]

youtube.com/watch?v=sp21CPC...(Not working as expected?)