1966 article

[Bluebell7575]

gastrojournal.org/article/S....

Has anyone tried this medication? Is this steroid a possibility to reactivate the immune system? I have read that parietal cells regenerate on their own (they were previously thought to be static) so what’s to say they can’t regenerate with B12 treatment and remission of PA? While I know there is no cure, there are many of us who feel very well on treatment with no symptoms which leads me to believe this can be put into remission for some

I would love to hear your thoughts

[GoneWithTheWind1972]

Interesting article. I was on Prednisone when I was sent to a rheumatologist when doctors couldn’t understand why my body was in so much pain (prior to me questioning if it was the insufficient treatment of B12 )

That was during the start of Covid and my symptoms persisted and got worse. Fast forward to today, I’m still symptomatic and if the Prednisone would have reset my immune system should I have my Parietal cells and Intrinsic Factor cells functioning again in conjunction with me SC Methylcobalamin every day?? Or that the nerves require much more time to heal and maybe retesting these antibodies again? Maybe then I can gauge if this article has some truth to it. Possibly a new way of treatment for Pernicious Anaemia.??🤞🤞🎄🎄

[Bluebell7575 in reply to GoneWithTheWind1972]

Hi GoneWithTheWind,

I IM cyanocobalamin every week and feel quite well. Is it possible you’re under treated?

[GoneWithTheWind1972 in reply to Bluebell7575]

Back then I was under treated and that was when all the nerve damage occurred hence the pain. With my current treatment plan of daily methylcobalamin I have improved significantly but still have lingering pain most likely some permanent damage. I am optimistic with my current intense treatment for another year or so may provide some better results.

[Hockey_player]

"Remission" feels like the wrong term for this. The B12 in our diet needs to be shipped by intrinsic factor to get into our bodies where we need it. PA is when the shippers quit and stop shipping the B12. Some people can still have some seep in with daily high dose sublingual B12. But some require injections. You can think of the injections as an alternate mode of transportation. When you feel better, it is not because the shippers are behaving any better- they quit and are not coming back. It is because the B12 is getting into your body by alternate means. We are still not completely healthy because our intrinsic factor is still not working. But our bodies stop suffering from too little B12 as long as you get the injections frequently enough.

[Bluebell7575 in reply to Hockey_player]

I completely understand this. My thought is remission from the antibodies attacking the parietal cells. Some people with PA only have antibodies to intrinsic factor and not to parietal cells, therefore do not suffer from low stomach acid, atrophy, etc.

I wish I only had antibodies to intrinsic factor but unfortunately have both types of antibodies. If there is a medication or supplement to repair the stomach and put parietal cell antibodies into remission - that would be great.