Which form of B12 is best. My conclusion.

[WIZARD6787]

I have concluded to my satisfaction that the best form of B12 is not known.

The information I reviewed was based on conclusions based on inductive reasoning which is made necessary as there is no test for the efficacy of the different forms of B12 at the cellular level.

The inductive reasoning used was not about symptom reduction it was about blood levels which has been proven to my satisfaction has no value as far as successful treatment the way the results are measured and the results are applied regardless of symptoms.

The only source I have is those on this forum. "Works for me" the issue with that is the individual is deciding what "works" mean.

I at one time stated that sublingual administration "works for me." I was not in error. It worked compared to what else I tried and a world of difference than no treatment at all.

I can find out what the best form of B12 is for me. It is going to take at least 1/2 year and will not be easy. I do not know if I am up to the task. Thing is I can live with that reality.

That we are all different is true. That is the extent of the value of that conclusion. It is a platitude for me.

[Nackapan]

I think b12 is b12 .I would use your energy on other things .

You work hard to work things out .

Give yourself a break.

I too like answers.

I don't even know the cause .

Ruled loads of things out.

Just know what's working to keep as well as possible.

The tests arnt robust enough and b12 deficiencty complex.

Whatever the reason we need b12 .

What ever is available

to inject .

I've done symptom charts

Pain relief charts

Vitamin charts

B12 injection regime charts

Pain severity charts

No professional medic ive seen interested.

One neurologist scanned them but didn't comment

3 generations in my family.

All had different symotoms and need a different b12 regime.

[WIZARD6787 in reply to Nackapan]

Hey Nackapan,

Thank you for your reply.

"I think b12 is b12" My brain agrees with you. My body did not get the memo. 🙂

Cobalamin is cobalamin, how my body uses the form is different.

I do take it easy when not working. Right now I can do open water swimming until it gets too cold. 🙂

How do the different members of your family decide what is needed for them?

[Nackapan in reply to WIZARD6787]

Went by symptoms. Didn't change too many things at the same time.

My mum. definitely didn't overthink it .

She wants for change.

Open water swimming sounds great . Bu dsughtef died that when she can.

I'm not back to swimming and cycling yet

[Hectorsmum2]

my main b12 symptom is incontinece. One type of B12 injections did not help with this another does. so there appears to be a difference.

[WIZARD6787 in reply to Hectorsmum2]

Thank you for sharing. I experience stomach issues/ incontinence every time i change amounts or forms.

[Nackapan in reply to Hectorsmum2]

That's interesting. I eas just told so many times b12 is b12.

One friend tried all 3 sorts on a trial basis.

She wax convinced methylcobalabin would d be better.

It wasn't so she went back to cyanocobalamin. Common in Canada.

I thought it converts once in the body to the sane thing .

A scientist woukd know.

What I know affects different people is the additives.

They do vary .

So I suppose different kinds of b12 have to have exactly the same additives to compare.

[Technoid in reply to Nackapan]

Yes, all B12 forms convert to cobalamin (the base molecule) and are then converted into the other forms as needed. If you take methyl, adenosyl or hydroxo, these parts of the B12 (ligands) are not used when the B12 is rebuilt in the body into the needed forms.

But because the forms are not bio-identical, different reactions to different forms are possible. For example with methylcobalamin you are also getting extra methyl groups (the methyl part of methylcobalamin) along with your cobalamin. For some people that may be just what they need, for others not so much. I think we see that in the diverse responses to methylcobalamin.

[am111]

I think different forms may be similar, but cyanocobalamin is absorbed less than others (there are charts on this from several papers), so one has to be careful while switching. Also, there is more variation in blood serum levels with hydroxy and methyl forms, which may make a difference. My body reacts slightly differently to different forms. I prefer cyanocobalamin, as it seems to be more diffuse and seems to give me more uniform B12 throughout the day (I SI 80mcg/day currently).