Inherited and acquired vitamin B12 deficiencies: Which administration route to choose for supplementation?

[dot-dash]

Open access review article from Frontiers in Pharmacology, Sep 2022, may have been posted already: doi.org/10.3389/fphar.2022....

Vitamin B12 or cobalamin deficiency is a commonly encountered clinical scenario and most clinicians will have familiarity prescribing Vitamin B12 to treat their patients. Despite the high prevalence of this condition, there is widespread heterogeneity regarding routes, schedules and dosages of vitamin B12 administration. In this review, we summarise the complex metabolic pathway of Vitamin B12, the inherited and acquired causes of Vitamin B12 deficiency and subsequently highlight the disparate international practice of prescribing Vitamin B12 replacement therapy. We describe the evidence base underpinning the novel sublingual, intranasal and subcutaneous modes of B12 replacement in comparison to intramuscular and oral routes, with their respective benefits for patient compliance and cost-saving.

(posted by @B12tektort on twitter)

[Orchard33]

They only have to ask the members of this forum about the efficacy of SC treatment. We constitute a trial that could provide evidence.

[WIZARD6787]

Interesting article. Thank you. I read it and my take away was I can raise my level of serum B 12 easily and that makes no difference to me. I do not have my notes here in the UK. From memory I raised my level from 698 pg/ml to >2000 pg/ml in a week with cyanocobalamin .5 mg every other day in two weeks. So what?