B12 Breakthrough?

[headypuma]

Hi everyone, I want to share a little bit about my journey in case it's helpful to others. There are some notes here for what I'm about to say:

app.hspconnection.com/forum...

I have two things to share:

1. I started doing methylcobalamin injections several years ago and it really helped me recover a very badly disregulated nervous system. I worked my way up to injecting 4mg/48 hours which I realize is extremely high, but that's what worked for me. As I've mentioned in other posts, I was (and still am) using the Oxford Biosciences powder, but then the quality of that diminished last year when they lost their source and switched to a new one. Per the notes in the link above, I just realized the importance of adding in adenosylcobalamlin and hydroxycobalamin, with significant results. Before reading that info, I didn't know it can be important to mix them. Everyone's different of course....

2. The other thing that jumped out at me is that MeCbl is tied up with blood formation, whereas AdCbl is relevant for fat metabolism (very important if you do keto) and nerve mylenation. And here's what I'm VERY curious about:

"Methylcobalamin that is ingested is not used directly as a cofactor, but is first converted by MMACHC into cob(II)alamin. Cob(II)alamin is then later converted into the other two forms, adenosylcobalamin and methylcobalamin for use as cofactors. That is, methylcobalamin is first dealkylated and then regenerated."

I'm wondering if this may be another reason why some people cannot get the same results from oral as from injections (like myself). I've been tested for intrinsic factor and that was not an issue, but there's no contest for me between injections and oral. And I'm wondering if it has to do with the conversion into Cob(II)alamin and then into adenosylcobalamin and methylcobalamin for use as cofactors. If something is broken in that pathway, that might explain why I need to inject and, why I am benefitting from adding adenosylcobalamin (oral).

[Technoid]

All forms of B12 are broken down to the base cobalamin molecule before being rebuilt into the active forms (adenosyl or methyl) as necessary. In theory it should not make any difference (in terms of effectiveness) which forms is used other than (likely rare) genetic issues with B12 metabolism affecting conversion. Thats aside from allergic reactions or side-effects that some B12 forms may have on some people.

[headypuma in reply to Technoid]

Thanks for your reply Technoid. Your response led me back to the video in the link I posted. Dr. Lynch's point is that cyanocobalamin is:

a) a synthetic form of B12

b) it is utilized but it's a "demanding" process for the body to convert it into MeCbl and AdCbl, a process which requires other nutrients.

So essentially, he's saying that cyanocobalamin is a cheap, synthetic substance that puts a load on the body. He then goes on to give specific use cases for methyl, adenosyl, and hydroxo forms. Pretty helpful I think.

Personally, I can say that my body hates cyanocobalamin and loves methylcobalamin. The breakthrough for me is that I can get (need actually) additional benefits of adding in adenosylcobalamin and hydroxycobalmain to my methylcobalamin injections.