How MTHFR mutation can affect cyanocobalamin injection?

[Hamayeshguy]

Does MTHFR mutation affects enzymes related to cyanocobalamin processing after injection. What ethnicity have more MTHFR mutation? Is there any other mutation affects cyanocobalamin injection required enzymes for processing.

[Jillymo]

Does MTHFR mutation affect B12?

MTHFR stands for methylenetetrahydrofolate reductase, which is why it is called MTHFR. It is a genetic mutation, and approximately 30% of the population worldwide has it. The mutation affects the ability of the body to turn vitamin B12 and folate into forms the body can utilize.

What vitamins should you take if you have MTHFR?

It's important to opt for a supplement that contains the most bioavailable form of folate—methyl-folate—which can help your body absorb the vitamin more efficiently. Additional supplements that help support this genetic variant include magnesium, vitamin D, and vitamin B6.

ncbi.nlm.nih.gov/pmc/articl...

[wedgewood in reply to Jillymo]

Thanks for that clear explanation 👍

[Hamayeshguy in reply to Jillymo]

Based on some articles south Asians and Hispanic ethnicity has more MTHFR mutation than the the rest of other ethnicities. In south Asia methylcobalamine injection is mostly dominant in market but in other countries cyanocobalamin. I think through time health systems are shaped to match requirements. But in south America with Hispanic dominance ethnicity I don't know why still cyanocobalamin is being used or even folic acid. In the meantime variants of MTHFR mutation cause completely lack of proper enzymes to process cyanocobalamin and folic acid are rare and even the worst variants can still to somehow process cyanocobalamin and folic acid. I'd appreciate if anyone knows more about real number of people who suffer from MTHFR variants with completely lack of processing enzymes

[Jillymo]

This is something I found documented by the Cleveland Clinic -----

As a geneticist and researcher, I believe in the power of genetic testing. By identifying genetic mutations, we can improve care and save lives.

But just because we can test something doesn’t always mean we should.

Take the MTHFR gene, for example. MTHFR codes for an enzyme that helps your body convert homocysteine into an amino acid that processes proteins. People with homozygous (present in two copies) mutations or variations of MTHFR may end up with homocystinuria, a disorder that affects the eyes, joints and other parts of the body. High homocysteine levels also have been connected to heart disease and strokes.

There is a genetic test for MTHFR variations. But there’s also a cheaper and more accurate way to test for whether MTHFR variations are causing disease. We simply check the levels of homocysteine in the blood. If levels are high, we can react appropriately. If homocysteine levels are normal — even if there is an MTHFR variation — then nothing needs to be done clinically.

[Hamayeshguy in reply to Jillymo]

There is an article regarding distribution if MTHFR C677TTgenesandnutrition.biomedcen...

According to some other articles people with both parents gene MTHFR mutation are more likely to infect with autoimmune disease like lupus, fibromyalgia, hashimoto. Methy folate and B12 other than cyanocobalamin can help them. These people also more likely to have hormone imbalance

[Jillymo in reply to Hamayeshguy]

The link was a bit technical for me to really understand.

Lets assume we have this factor - would it make any difference with regard to our treatment ?