Lightheaded

[CDALY474]

B12 was 126 given cyanocobalmin tablet (1) and 1 injection had horrible reaction. Found out I have trouble methylizing. Took hydroxcobalim no reaction able to tolerate. I am not anemic. But still have a weird lightheaded pressure in my head. I am only taking capsules of the hydroxcobalim because doctor refuses injections unless they are cyanocobalmin. I guess my question is, did anyone who is not anemic have this head sensation with the b12 deficiency or is it something else.

[Nackapan]

Yrs it's a neurological symptom

[fbirder]

You do not 'have trouble methylating'. This is meaningless gobbledygook spread by people trying to scare others out of their money.

There is one mutation that might possibly affect you, homozygous for C677T on the MTHFR gene. taking 400 mcg of methylfolate each day will negate any possible side effects.

[CDALY474 in reply to fbirder]

There is a COMT gene defect thst can cause severe agitation, anxiety, restlessness when you take cyanocobalmin and methycobammin. It has to do with neurotransmitters and methylizing. So yes that’s trouble methylizing. Hydroxocobalmin and adenocobalmin don’t cause this reaction. That was not my question I was just giving a background. But thanks.

[fbirder in reply to CDALY474]

Really? Do you have a reference to this?

I'd be surprised if cyanocobalamin caused any problem with methylation.

Indeed, B12 isn't involved at all in the action of catechol O-methyltransferase.

[CDALY474 in reply to fbirder]

innovationcompounding.com/c...

This link shows that cyanocobalmin is converted to methylcobalmin once the cyanide is removed from the liver.

geneticlifehacks.com/comt-g...

This link will show you that people with the COMT/trouble methylizing should take hydroxcobalmin or andeocobamnin to prevent the reaction of coming out of skin, agitation and restlessness. It’s at the bottom under methyl donor groups.

Again this has nothing to do with my question about the odd pressure/lightheadeness in the back of my head. I thought the lightheadedness would be from being anemic which I am not.

[fbirder in reply to CDALY474]

First link:

This isn't science. This is advertising blurb from a company trying to sell you methylcobalamin. Science is a peer-reviewed journal. Science like this -

ncbi.nlm.nih.gov/pmc/articl...

Science that shows that cyanocobalamin does not have the cyano group removed in the liver, but in the cell after the cell has imported the B12 from the blood. Science that shows that all forms of B12 undergo the same process.

As soon as any form of B12 enters the cell, the top ligand (hydroxo, cyano, methyl, adenosyl) is removed to form cob(II)alamin. This is then transported to wherever it is needed in the cell.

So, when you take methylcobalamin it is converted into cob(II)alamin. And when you take cyanocobalamin is is converted to cob(II)alamin. The two are identical.

[fbirder in reply to CDALY474]

The second link is much better. It includes references to real science. Except for when it claims that methylcobalamin should be avoided by people with a specific COMT mutation. That's annoying, because that is evidence that I've failed to find. I am heterozygous for SNPs at 14 locations on the COMT gene, including being AG on RS4680.

I know that methylcobalamin has really bad effects on some people, including me. I know those effects are similar to those I experienced when I took an experimental dopamine antagonist. I know that some people have proposed a link between these effects and COMT mutations. But I cannot find any real science.

Actually I think I need to talk to the author of that second link. Thanks for finding it.

[Gambit62 Administrator in reply to fbirder]

fbirder - I will try to see if I can find the article but I have come across some bits on the part B12 plays deep within an article on COMT - it does seem to be a co-factor in the reaction but the relationship isn't a linear one but is an inverted bell curve - meaning that there is a range where things are okay and then everything goes totally haywire if there is either too much or too little B12.

[Gambit62 Administrator in reply to Gambit62]

mention of COMT in section 8.3 sciencedirect.com/science/a...

think its also buried somewhere in this article

jbc.org/content/early/2014/...

[fbirder in reply to Gambit62]

Thanks.

I emailed the person that wrote that article. She said that she couldn't find anything to confirm it, but felt compelled to include the bit about methylcobalamin and COMT mutations because a family member had the same problems as many here did. As she put it - "That is one of the few things that I’ve included on Genetic Lifehacks without any research studies to back it up."

[Litatamon in reply to fbirder]

Here is what I am not getting -

Listing only hydroxocobalamin and adenosylcobalamin. Why was cyanocobalamin not listed then?

-------

It is interesting about some of our intense reactions to methylcobalamin.

I have -

COMT V158M rs4680 AA +/+

COMT H62H rs4633 TT +/+

[fbirder in reply to Litatamon]

I've no idea why cyanocobalamin wasn't included. I've emailed her to ask.

[Litatamon in reply to fbirder]

No reply as yet?

[fbirder in reply to Litatamon]

I got a reply earlier this afternoon.

She was worried about recommending a form of B12 that can produce cyanide, even in small amounts, because a lot of people that read her site have problems with various detoxification processes.

I'll be replying tomorrow, pointing her to my calculation to show that 1000 mcg of cyanocobalamin has the potential to produce as much cyanide as 7 apple seeds. b12science.com/B12Science/D...

[MoKayD]

During the first year or so of receiving my loading doses and monthly B12 shots I would have strange sensations in different parts of my body. For a time I would get a really bad headache for the first day after my shot. It would go away within 24 hours and now, 2 years in, I don't have any reactions after my shots. I believe these reactions were from nerves healing in different spots within my body. The only thing I am feeling now after a shot is tingly sensations in the toes, which are continuing to heal. Hang in there and keep getting your shots, eventually your body will be healed.

[Litatamon]

Hi,

I had that sensation before treatment.

You're only on capsules right now, correct? Could it be possible that this is a symptom of not absorbing ie. needing the shots/not enough b12?

[Ryaan]

Yes it’s one of the symptoms of low B12.

It can also be low Iron or low Folate and also a symptom of low blood pressure so best to get them checked also.