Liver toxicity and B12

[EllieMayNot]

I am currently being treated for PA, self injecting every other day with my GP's approval. I saw a recent post that is now closed related to liver health and B12. Due to repeated environmental exposures to various toxins (formaldehyde from flooring, chlordane from the yard) I have a very "sluggish" liver and several issues associated with it along with a family history of NAFLD.

It is my understanding that with liver issues, it is suggested that the need for B12 is increased. I am wondering if this might be the reason why even before beginning B12 injections, my B12 serum levels were in the middle of the "normal" range yet I was suffering from ever increasing neurological symptoms. It has been suggested that with liver issues, functional B12 issues arise.

If anyone has a deeper explanation, I would love to learn more.

Thank you for your time.

[Fl17]

Off topic, but I've heard milk thistle and dandelion root is good for liver, something you can look into. Not entirely sure ..

Dr. Mindi Pelz has info on toxicity, and proper? fasting. Dr. Berg, Pompa, Axe, may as well on similar topics.

Best wishes.

[EllieMayNot in reply to Fl17]

Thank you. I am looking at a few different liver detox formulas/protocols. Am a big fan of Dr. Pompa, will check out the others as well. I appreciate the input!

[Fl17 in reply to EllieMayNot]

Np. Wow, so glad you know who he is. Dr. Mindi Pelz has info on toxicity that you can check out on YouTube. She has an informative and fun instagram account as well. Cheers ..

[Fl17]

You can look into fasting and Autophagy if you'd like, and of course check with your Doctor with what you pursue.

Dr. Pompa talks alot about stem cells. He dicusses release of them after 5 days of fasting? Can't remember if some sources say 3-5 days?

A dry fast may help with detox issues, you can check with a medical expert.

16.5 hr intermittent dry fasting may reap some huge benefits, and seem attainable, and can 'safely" be worked up to longer fasting, oked by your Dr.

Might want to start with 12s and 14ws before 16s, see what the experts and your Dr. says.

Dr. Leland is another you can check out.

Ox

[Gambit62 Administrator]

"with liver issues, functional B12 issues arise".

If you are on B12 injections this is irrelevant.

Raised serum B12 is recognised as a potential marker of liver (and kidney problems). In the case of liver problems it is caused by something going wrong with the liver's ability to store B12 with the result that stores are released and end up in the blood stream. With kidney problems levels are raised because the mechanism that removes B12 not bound to proteins that either allow it to be stored or to pass into cells stops working efficiently and levels build up.

Raised serum B12 levels can, in a significant number of people, be associated with the symptoms of B12 deficiency = functional B12 deficiency.

This paper is about the use of raised serum B12 as a potential early marker for liver and kidney problems and talks about the irony that raised serum B12 may result in the symptoms of B12 deficiency

academic.oup.com/qjmed/arti...

There are a large number of processes that use B12 in peoples cells and an even larger number of genetic variations that can affect how efficiently these processes run even when B12 is available and getting into cells. The range for serum B12 is extremely high - some people naturally sit towards the top of the scale ... others towards the bottom (and a few will actually sit above the top and below the bottom of the normal range).

If you have an absorption problem, or you if you have a B12 storage problem (liver) then what will happen is that serum B12 levels will start to fall. You can't tell if levels are falling from a single result ... and as the serum B12 test is only accurate to 20%, looking at levels over a short time interval (weeks) may not give a detectable fall, as it generally takes years and in some cases can take decades for stores to be depleted and hence for levels to fall.

[EllieMayNot in reply to Gambit62]

Thank you for the very thorough explanation and reference paper, much appreciated!