So, I did the 23andme DNA test and it turned out I had several SNPs including Homogeneous MTR/MTRR. I recently had done a blood test and my homocysteine levels were 19.8 which was quite high as I'm in my late 20s and have a healthy diet. In addition to all this, I have all the classic symptoms of b12 deficiency like balance issues, mental fog and memory function, moods issues, low energy, sleep issues etc. I tested for b12 and it was around 400 which was normal.
I then started taking high daily dose 5000mcg methylcobalamin and occasionally methyfolate and other Bs and TMG for several months. I checked my homocysteine levels and they were significantly lowered (9) yet my b12 levels did not even change and my symptoms remain largely the same. I don't know what to do as I really want some mental clarity and help with sleep.
Any suggestions? My thyroid seems to be fine and it doesn't seem to be depression as I have naturally high levels of motivation and normal social life thought lack of energy and mental clarity does have a negative effect on them.
Thanks,
Written by
Hindi1989
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If you have an absorption problem in gut eg PA (Pernicious Anaemia), Coeliac disease, gut damage due to H Pylori infection then oral tablets/lozenges may not make a lot of difference to B12 levels.
"What You Need to Know About Pernicious Anaemia and B12 Deficiency" by Martyn Hooper
Martyn Hooper is the chair of PAS (Pernicious Anaemia Society). Book is up to date with most UK b12 guidelines.
"Living with Pernicious Anaemia and Vitamin B12 Deficiency" by Martyn Hooper
Has several case studies.
"Could it Be B12?: An Epidemic of Misdiagnoses" by Sally Pacholok and JJ. Stuart (USA authors)
Very comprehensive with lots of case studies. There is also a paediatric version of this book "Could It Be B12? Paediatric Edition: What Every Parent Needs to Know".
Variants on both can make the methionine process run less efficiently and result in high levels of homocysteine.
This is very different from having a problem absorbing B12 which leads to a B12 deficiency..
The symptoms you are reporting are probably down to this process running less efficiently rather than a specific B12 deficiency - the symptoms overlap because B12 is needed by the process so B12 deficiency will make the process run less efficiently.
Treatment of genetic problems is well beyond the remit of this forum.
This link provides some links to management guidelines
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Mystery bloods
Low 'normal' B12 and high folate - B12 deficient?
B12 makes me anxious and jittery 
Top of Range Active B12
