PA : High Gastrin & Low Pepsinogen

[tnkarthik28]

Dear PA community, i have PA & Atrophic Gastritis with high Gastrin & very low pepsinogen. Though I take HCL+Pepsin tablets with my food for better digestión, after 7-8 months of continous in take of these tablets+lemon juice before meals, the latest blood test results shows still very high gastrin of 750(supposed to be less than 100) & pepsinogen - 2 (supposed to more than 25) so dont know what to do. Is there a way to reduce gastrin & increase pepsinogen? If I am not mistaken high gastrin will lead to tumors, right? but dont know the side effects of low pepsinogen. please advise.

[fbirder]

High gastrin can, not will, lead to the development of Neuroendocrine Tumours in a small number of people with Autoimmune Metaplastic Gastric Atrophy. Even if you do develop NETs they are, in the words of my gastroenterologist, indolent. When I was told that I had NETs I did some research and found that the five-year survival rate for those of my age with NETs was a little better than for those without (I guess we have more monitoring to catch other things).

If you’re worried as for a gastroenterologist referral for a gastroscopy every few years, just to check for them.

I don’t know of any adverse consequences of low pepsinogen.

[tnkarthik28 in reply to fbirder]

many thnx fbirder

[genesurf]

Maybe you could try increasing your frequency of B12 injections?

I found a 2011 study on oral lichen planus that shows Antiparietal Cell Antibody production falls over time with weekly hydroxoB12 injections. Going from that idea... more B12 means lower levels of APCA to destroy existing parietal cells. Then, if there are enough residual parietal cells to allow the body to make more HCl again... then higher levels of natural HCl might reduce gastrin production.

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Effective vitamin B12 treatment can reduce serum antigastric parietal cell antibody titer in patients with oral mucosal disease Andy Suna,b, Julia Yu-Fong Changa,b, Yi-Ping Wanga,b,Shih-Jung Chenga,b, Hsin-Ming Chena,b, Chun-Pin Chiang

Patients were given weekly intramuscular injections of 1000 mcg hydroxocobalamin, and also b-complex, and folic acid, iron, or zinc depending on need. Their symptoms resolved, and APCA levels dropped. A later phase of the study removed the B12 injections, and the patients' progress reversed.

There's also an interesting discussion of the interactions of APCA and the body.

Link is here:

ncbi.nlm.nih.gov/pubmed/206...

Fulltext here:

kundoc.com/pdf-effective-vi...

[tnkarthik28 in reply to genesurf]

thank you so much genesurf for the valuable info. vl try with weekly injection for 3 months n vl update you all.

[genesurf in reply to tnkarthik28]

Well, there are a lot of "ifs"! But It might work, in theory-- I hope it does. Please let me know how it goes... whether it changes your gastrin and APCA levels, or not.