sublingual b12 recommendation - Pernicious Anaemi...

Pernicious Anaemia Society
22,470 members15,861 posts

sublingual b12 recommendation


hi there, I wonder if anyone an recommend a good sublingual b12 - there seem to be so many out there with a huge range in pricing, so no idea where I should start.

I'm coeliac (diagnosed 2 years ago, decades of symptoms, recent biopsy showing good signs of recovery but still damage), hashimotos (my instinct is that this is well controlled with thyroxine). But more often than not (3 days out of 4) I suffer with bad diarrhoea in the morning, followed by exhaustion, dizziness, slight vision disturbance (can't be sure this isn't just exhaustion to be honest) so am rather clutching at straws and wondering about b12 deficiency. I should add that I am religiously careful about gluten and have tried just about every exclusion diet known to man (woman) kind with no effect.

Rather wonderful GP is running tests but won't get results til Tues, and am off for a month of camping with kids (this may not be my best thought-out plan... :D) on Thursday. So am thinking about getting in some b12 in advance and giving it a try if the doc doesn't come up with any concrete suggestion from all the tests he's running.

thanks in advance


5 Replies

It’s very unlikely that you have Pernicious Anaemia as this is caused by autoimmune gastric atrophy, and that would have shown up during the endoscopy where they took the duodenal biopsy. That means that you should be able to absorb B12 from the gut. Which is good, because I don’t believe B12 can be absored sublingually.

There’s virtually no difference in the various tablets you can get on Amazon. I always went for the cheapest. Don’t bother with the stupidly high doses, 1000 mcg should be plenty.

in reply to fbirder

thanks fbirder - that's interesting. And that gastric atrophy would show up obviously different to the damage caused by coeliac would it?

in reply to Tillyxx


Gastric atrophy is damage to the stomach lining. In Pernicious Anaemia that damage is restricted to the top parts (fundus and body) so it’s pretty obvious.

In coeliacs the damage is to the duodenum - the first part of the small intestine. In particular the small protrusions called villi.

Thanks again fbirder. Makes perfect sense. Will look for another straw to grasp at.

in reply to Tillyxx

However, although you don't have PA that doesn't mean that you may not have a problem absorbing B12 - coeliacs is listed amongst the possible conditions that can cause problems absorbing B12, though if your coeliacs is under control then it shouldn't be affecting your B12 levels.

If you have had a serum B12 test in the past then it would be useful to do a comparison of the two to see if there has been a significant fall in levels.

Folate deficiency will also have the same symptoms.

Supplementing at this point is going to cause problems if you need further tests later on.

You may also like...