Autoimmune gastritis/PA: Hi everyone... - Pernicious Anaemi...

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Autoimmune gastritis/PA


Hi everyone,

Im wondering if anyone could give me any advice please.

I had an endoscopy yesterday, it revealed multiple ulcers and oesophagitis. I’ve been put on omeprazole for 8 wks then a repeat endoscopy to see if any improvement.

I thought omeprazole inhibits acid in the stomach but I already have low acid. I’ve asked my GP today that as I tested negative for H pylori could the ulcers be caused by my autoimmune gastritis and if so will omeprazole help me? He wasn’t really able to answer me.

I don’t smoke, I have a good diet so can’t understand why I have them. It seems they have been there for some time, I was getting severe non cardiac chest pain which is why I was referred for endoscopy. I was scared witless but so glad I went.

I was diagnosed with PA 3 yrs ago, Intrinsic factor antibodies test was positive. I’d had PA undiagnosed for many many years so have lots of symptoms. I know I’m one of the lucky ones as my GP is very understanding, after my loading doses I have had injections every 4 wks ever since.

I’m nowt afraid I will be treated as someone with ulcers caused by H Pylori or Campylobacter instead of autoimmune gastritis. I did mention I had PA at my original consultation.

Many thanks. 😀

Sorry for moaning! 😂

4 Replies

Hi there: you are luckly you are on B12 shots (parenteral application), for if you were not, proton pump inhibitors (omeprazole is one of them) would block absorption of regular B12.

Unable to upload manufacturer's pamphlet PDF regarding drug interactions to sublingual B12, but here's excerpt including anti-ulcer drugs as well:

======== Drug Interactions


Excessive alcohol consumption, antibiotics, anti-acne

drugs, anti-retrovirals,

anti-gout drugs, antihypertensives, anti-tuberculosis drugs, anti-ulcer drugs, biguanides (oral anti-diabetic drugs), histamine (H2) blocking drugs, oral contraceptives, proton pump inhibitors, sulfonamides (antiinfectives),

tetracyclines (anti-infectives) and

epilepsy (seizure) edications can deplete Vitamin B12 levels. === Suggest you bring this up with your doctor. Best of luck!

in reply to Hidden

Thank you so much for your reply Adrienne,

I have discussed Omeprazole with my doctor, because of PA/ autoimmune gastritis I don’t have excess acid therefore I don’t need proton pump inhibitors. My GP agrees with this! PPI treatment is for people without PA/autoimmune gastritis.

I can’t seem to find any treatment for ulcers caused by gastritis other than PPIs or other acid suppressing meds. I’m worried that by asking me to take them for 8 wks prior to next endoscopy I’m being treated as someone who has developed ulcers for reasons other than an autoimmune disease attacking my stomach lining.

Has anyone else had this problem? I’m not sure where to turn really.


in reply to Sleepyfromwales

Noted and best of luck. Reviw this link I located for relative in UK with Chron's. All supplements and foods can also be used for those with gastritis, note that I take DGL 3x/day, Boswelia (Frankinsence, from India or Somalia) by Swanson's 1x/day. Apply hot towels compress to GI area, after gentle massage with quality lavender oil.

in reply to Hidden

Thats brilliant thank you. :)

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