I just thought I would share something that has helped me greatly...
Been suffering with chronic fatigue, memory loss, concentration and balance problems, mental health... list not exhaustive! Ha! For the last couple of years. Started 3 monthly injections recently. They took a while to kick in but I still felt awful and dreading waiting the 3 months. I did loads of research online and read about sublingual b12 supplements. Basically you put the tablet under your tongue and it is supposed to go straight into your bloodstream so works even for those with pernicious aneamia as it doesn’t have to go into the stomach. After 2 weeks people started to comment that I seemed “brighter” and “happier “. I honestly think they work and want to help others stop the awful symptoms. I definitely have tired days still but I feel so so so much better and more positive. I don’t sleep as much, I’m more awake.
Bye for now!
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Teriburke
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Like wedgewood, I find that sublingual lozenges, throat sprays and skin patches to absolutely nothing for me.
To be absorbed across the membranes in the mouth a molecule needs to be fat-soluble and small. The B12 molecule is water-soluble and large. Perhaps it is right on the borderline so it is absorbed by some and not by others.
As with other things, individuals need to (quite literally) ‘suck it and see’.
Sorry it hasn’t worked for you Wedgwood and fbirder but glad to hear that the injections are working.
FI17 did you feel the sublinguals helped you at all? It does feel like we get left to sort it ourselves as the medical profession don’t take it seriously.
Yes usually on an empty stomach. Seriously need to change my diet now I know I’m gluten intolerant.. just constantly feeling sluggish due to diet on top of the anaemia! So very Glad you’re feeling better
Hi Teriburke, which tablets do you use? I thought about using sublingual tablets but my limited research concluded that the sublinguals contain a different form of B12 than the injected form and was less effective.
Most sublingual tablets are methylcobalamin, presumably because a lot of websites falsely say that it is he best type. But I’ve also seen adenosylcobalamin and cyanocobalamin.
When any form of B12 enters the cell the top ligand (methyl, cyano, etc) gets removed, so they should all be effective.
Some people can have a bad reaction to methylcobalamin. I’ve tried injecting it once - never again. But I can take doses 50 times bigger as sublinguals and I get nothing bad (or good) which is he main reason I think I’m not absorbing it.
I use Vitamin B12 1000mcg Sublingual Tabs by Lindens UK. Yes they are less effective but taking them every day I feel like the b12 is constantly building up rather than going down waiting for my injection. I will still get the injections of course but I feel this is helping in the interim between them
I also get a bit of a lift from sublinguals but I find I have to take a lot - like up to 15000 mcg (i.e. 15 pills taken throughout the day). But injections do help me more. I take hydroxo lozenges by AOR. Only side effect to the lozenge is that it seems to cause a bit of heartburn which is weird. I may try different brands and see how it goes.
I’ll get back to you on the brand won’t be long... glad to hear the sublinguals are working for others too. I think whatever works we have to run with!!
Mistydawn i read that there’s 2 type of b12. One in the injections that is already b12 when it goes in the system... and the one in the sublinguals which converts to b12 inside the body
No. The sublinguals contain B12. Just in a different form (methylcobalamin) compared to the injections (hydroxocobalamin). Both types are converted to cobal(II)amin in the cells.
the only subliqual that works for me is the methycobalamin form under the tongue...the cyano did nothing.....
edited by admin
I got my father (80) to check his levels & it was 250 which of course NHS say is fine so just got him to start taking sublinguals daily using the line that you don't wait for your car to run out of petrol before you put some in, and I've noticed he's had more memory issues and falling over a couple of times of late so hopefully this will help.
Amazon UK has best naturals 6000mcg ones £11.99 for 60 which is a good price so got him those - secretly it's my experiment to see if he has the absorption problem - I believe some gets through even if you do so hope this helps raise his levels. I tried the Jarrows 5000mcg ones & got through a whole bottle in a few days but didn't feel a thing.
My mother's level was 678 but she has all the signs of deficiency so now getting her to get a urinary MMA, will be interesting to get results of that as she has high platelet levels & saw one other report of someone who had functional B12d which was causing high platelet levels.
Anyway just thought I'd post as those 6000mcg ones have only recently appeared on amazon and I have the same brand B2 tablets which seem to work OK cos I pee bright yellow lol!
Level of 80 and also pernicious anemia- I’ve had my six loading doses and have appt with the doc tom armed with the NICE guidelines as feel no better. I’m wondering whether to try the sublinguals anyway whilst waiting for the next injection which will be approx 11 weeks from now.
It seems patients have to take matters into their own hands / lives with this so I’m looking into all options. Can anyone advise any reasons why trying the sublinguals might NOT be a good idea at this stage ?
I just tried them anyway as couldn’t feel worse than I already did! Helped me massively. Doesn’t help everyone though worth a try. Took about 2 weeks to kick in
I also take tablets - never had injections. Been taking them now for a few years and outcome is current GP did blood test which included B12 and found it high at the time - couple years back now. Said 942 and 440 ml usual. Anyway I was taking 1000 mcg daily and he said go to 3 times a week. So I did. And gradually nerve pain in left heel which was reason I took B12 in first place started to comeback - get it in bed like most nerve pains.
So back to daily and feel so much better too - more with it. Realize I had neglected things for a while I usually was on top of etc. Its more necessary than seems to me GP's are trained on. I had PN age 15 and never got told it for for life.
Do keep them up - do the job obviously as well as having an injection and a lot less painful eh!
Read up on it and find lack can cause dementia, confusion etc etc. Makes me wonder how many others are short of B12 and never tested as not sure it is in standard blood tests.
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but glad to hear that the injections are working. 
Depression after sublingual B12
B12 levels on sublingual hydroxycobalamin.
Can sublinguals help to supplement b12 between injections? 
