I was experiencing severe fatigue and occasional depression for maybe a couple years and eventually peripheral neuropathy (pins, needles in hands and legs, a couple numb fingers on my right hand, and "MS hug"). The neurological symptoms came on over 5 months just prior to the diagnosis, and prompted me to see a doctor. I was diagnosed with B12 deficiency about 2.5 months ago. My out of range blood readings were HGB = 10.8 g/dL, HCT + 32.9 %, MCV = 108.2 fL, MCH 35.5 pg, MCHC = 32.8 g/dL, and subsequently B12 = < 60 pg/mL. I'm assuming that "< 60" is a minimum detection limit or effectively zero!
I also showed high BUN (36 mg/dL) and slightly high Creatinine (1.6 mg/dL), which is a sign of a kidney function issue. Can the anemia cause that or is it the reverse.
I am two months into my B12 shots. I started on Cyancobalamin through my doctor (daily for a week, then 1/wk for a month) then, having read a lot more about the condition, I switched to Methylcobalamin and have been on twice a week shots on my own, and will continue that until my symptoms stop improving. I got my Methylcobalamin B12 from Oxford Biosciences (I live in Cleveland in the US).
My neurological symptoms have been improving since I started B12 shots, slowly, but definitely. My right fingers are no longer numb and I can now button, at least my right sleeve, and the MS hug is less tight. Also, my energy level has improved a lot and my depression is no longer creeping in.
I am reading "What You Need to Know About Pernicious Anaemia and Vitamin B12 Deficiency" by Martyn Hooper, but I have two questions that I was hoping someone here with experience could answer.
1) Should I consider the neurological symptom improvement over the last 2.5 months a positive sign and something that should continue over a few more months? My neuropathy was happening unabated for 4.5 to 5 months before I started my shots. I've read that it can take 6 months before symptoms have improved as much as they will. I am hoping that the improvement is a sign that the myelin sheath is
2) Is it possible to diagnose my case as Pernicious Anemia based on symptoms (or lack thereof) or should I have a test done for IFAB? My relatively ignorant doctor (former doctor) asked me why I even needed to know since "either way, you'll have to take the shots for life." I said "Well, if it's gluten intolerance that's causing the lack of B12 absorption, I'd like to know that." I refrained from adding a ", you dumbass" to my statement.
Anyway, I've done a lot of due diligence on this bu have not come up with great answers to the above questions and any input from this impassioned group would be a huge help. Thanks so much, Al