Methyl For SI ?? : I think I read... - Pernicious Anaemi...

Pernicious Anaemia Society

32,627 members23,989 posts

Methyl For SI ??

rockinHippy profile image
8 Replies

I think I read somewhere that this is a less painful injection??

I also think it might work better for the person who needs it as they've shown as having a gene mutation that means they can't process B12 as well, plus they need more than normal to stay well. We've hit a brick wall with doctors & as I already SI myself it makes sense. Also needles, I use needles I get from the drug exchange, which are nice and fine, but I wonder if you can buy even finer, less painful ones

The person this is for is very pain sensitive, so looking to SI as pain free as possible

Thank you

Written by
rockinHippy profile image
rockinHippy
To view profiles and participate in discussions please or .
Read more about...
8 Replies
fbirder profile image
fbirder

Methylcobalamin is not as good as hydroxocobalamin. It is more difficult to source, more expensive and less stable.

The gene mutation you're referring to is carried by about 9% of the population and affects production of methylfolate. Many people with that mutation function perectly well. Some may find that they feel better if they supplement with methylfolate. They have no need to take methylcobalamin.

I didn't find methylcobalamin any less painful the one time I tried it.

rockinHippy profile image
rockinHippy in reply tofbirder

Thank you for your reply. Interesting that one of those gene mutations is so common

I was hoping it would be less painful as I've seen that said about Methyl many a time. Hydroxocobalamin is excruciatingly painful for her & she just can't SI with it as a result & we need to go that route as she's getting worse again & we've hit a brick wall with her doctors

My daughter doesn't have the MTFTH gene mutation but another one & the blurb with it suggests she would fair better with Methyl, so I figured it worth trying for both reasons. I have Hydroxo here already & though I'm happy enough with it, it's just no good for her

wedgewood profile image
wedgewood in reply torockinHippy

I have used both , and found absolutely no pain with either. I now only use Hydroxo and use a large long needle to extract , because whilst extracting it is possible to blunt the end of the needle, which could make injecting painful. To inject into my thigh , I change to a shorter 1" needle with 25 gauge ( very thin). I inject very slowly , and never have any pain .

rockinHippy profile image
rockinHippy in reply towedgewood

Thank you. I do use Hydroxo for SI myself & do find it okay if warmed to skin temperature. I don't bother swapping needles though as I've not had a problem with blunting needles.

Unfortunately my daughters experience wasn't the same, not the needles going in, but the Hydroxo itself really burned her, she was in tears & I don't want to go through that again, so really want to try Methyl

Gambit62 profile image
Gambit62Administrator

Do you know if the hydroxocobalamin was warmed before it was injecting - injecting anything cold can cause a lot of stinging. Hydroxo is often kept in the fridge (doesn't need to be kept that cold) and there is often no realisation of just how much pain can be caused by injecting it cold.

B12d.org recently had a supply of methyl that they had to stop using because people found it stung a lot - think it was one of the preservatives/excipients that was causing the problem so it may be worth looking at other types of hydroxo with different preservatives if the problem isn't injecting cold.

Which form of B12 suits which person varies a lot - methyl does work better for some but it is far from universal and the exact reasons are far from clear ... and for some methyl actually seem to cause problems with anxiety and sensitivity to pain.

fbirder profile image
fbirder in reply toGambit62

The B12d problem occurred because the methylcobalamin wasn't buffered properly.

Hydroxocobalamin from Germany will have been prepared by a reputable source, with repeatable, tested formulations.

rockinHippy profile image
rockinHippy

Thank you for the replies. Food for thought, I really don't want to,waste money on something that might be worse, so,maybe we need to try again with the Hydroxo. I spotted an auto itect gadget discussed somewhere today & it sounded really good. Maybe that might be better to try first.

Thank you for your help everyone 😊

Galadriel1 profile image
Galadriel1

Hi rockinHippy , I use the auto-injector, it is really easy to use and holds the syringe securely, it has a safety lock so you don't accidently inject until ready a window area so you can see what you are doing and a light. You press button and needle goes straight in (not painful - better than when nurse does it), you then press plunger very very slowly and then I find it totally painless. As someone else said, warm up the ampoule beforehand, it really does work. I have needle phobia and couldn't do it without the auto-injector. The link is here: unionmedico.com/product/sup...

Not what you're looking for?

You may also like...

SI Help and Info

Hi All My preps continue...not buying anything yet though...just getting ready.. A few questions...
Treesong2023 profile image

Self injecting. No problem

Hi, I was diagnosed with PA in 2000 using the schilling test. For the past year my Dr. Keeps...
Tonyworks profile image

Travelling and SI B12

Advice please. The government guidelines are that you need a letter from your doctor to carry...
MrsTuft profile image

Where to buy SI supplies, also best brands and sizes.

Could people share where they buy supplies for SI? And the sizes of syringes and needles for...
Yahaci profile image

Si needles

I'm doubting the needles I'm using as to whether long enough. I ordered from Medicare. Can anyone...

Moderation team

See all
Foggyme profile image
FoggymeAdministrator
Gambit62 profile image
Gambit62Administrator
taka profile image
takaAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.