Hi all, I wondered if you guys can shed any light on my B12 mystery and blood test results when my serum level is the high side of normal? I don't get how this is possible as I've been vegetarian (I eat eggs and dairy) for 22 years but I'm wondering if my deficiency is functional, and if that can cause a high reading.
My GP refused to treat my B12 so I have trialled self injections. I was thinking it was dietary and I would be spreading out the injections by now but after ten loading doses I still crash badly after 2-3 days!! As I I have read you can't overdose, I have succumbed each time and just injected again as they are making a huge difference, I have my mental focus back and my energy is slowly returning. Sadly I never checked homocysteine or MMA beforehand.
I've just ordered an MMA urine test now which I've read could still potentially show as elevated if I have a functional deficiencyand am thinking of asking my GP for the IF antibody test. I'm also awaiting genetic results to check into the MTHFR gene from 23andme. What I don't get is how my B12 levels have actually increased over the last year before I started the injections or any serious supplements (I may have had the odd berocca but nothing more than that). I thought both results were on a par until I realised they were measured in different units and the most recent reading is really high when converted to pg/ml if I've done it right (I used an online calculator).
The only big change is that I managed to get my ferritin up from 8 at that time to over 100. Could that affect the result? Or can you somehow get a false high b12 reading from having absorption issues? I've just read a (albeit very old!) paper from 1967 (https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0029665167000412) stating that the average vegetarian has a B12 reading of 250 pg/ml so how on earth could my reading be 756?! The jabs are clearly making a difference, I have my mental focus back, and supplementing in between doesn't enable me to go any longer between jabs hence the suspicion of a functional deficiency. Am I going mad to even worry about all this?!
Serum B12 511 ng/L (or pg/ml) (211-900) (I did an online converter which said it's 377 pmol/l)
Serum folate 7.5 ug/L (4-20)
B12 558.2 pmol/L (140-724) (756 pg/ml)
Folate (serum) 11.04 ug/L (3.89-26.8)