Pernicious Anaemia Society

Why does this happen ?

aaaaargh!. every so often I get a half moon bubble at the bottom of the syringe that just will not shift. Now, I know from previous posts that a small amount of air won't do any damage, but I feel this is too large to proceed. This stays there even after I get a large bubble to go up to the surface. I am doing everything I've learned here, like pumping the syringe a couple of times to make it works more smoothly, then pushing the plunger right down so no air in the syringe before I draw up. No matter what I do, this bit of air at the bottom sitting over the black dome bit just sticks there. I have tried shaking the syringe, turning it sideways, upside down, flicking like mad, but nothing works. I put the solution back in the vial a few times and tried again, but still the same. I ended up dropping the whole thing on the floor and although the cap was on the needle, I threw the whole lot away with the b12 in the syringe just to be on the safe side. This really makes me so stressed as I always feel quite nervous doing the injections anyway, but this carry on makes me so scared to do it. Are they faulty syringes or is the B12 maybe too cold. Other times it goes so well, I just get confident then this throws me :(

6 Replies

Eaoz aoz, it's not tiny, it's just smaller than a thumb sized half moon (which are reappearing ). I don't understand why I get a bubble to come up but this stays. When I lay the syringe flat the big bubble joins up, but when I flick again, part bubble goes up but this bit over the black bit and wall stays. I have used two more syringes and it is fine with the third one ???


I do my daughter's I.V drugs and I'm always paranoid about bubbles, but one of the nurses told me that you have to inject a lot of air to really cause a problem. More than you would ever get as even a very large bubble in a syringe. It still doesn't stop me from trying to get out every one though ;)

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Hi Peggylally. Quick point - if the air bubble is sitting under the top of the plunger when you inject...just inject the B12 and stop when the last bit has entered the barrel end on the needle - then no air bubbles will go down the needle.

As other have said...even if some air did get into the muscle tissue, it won't hurt you. There aren't any large vessels in the upper outer thigh and even if you nicked a small vessel (which can happen occasionally) it would simply colllapse - so no way air could get into the vessel.

No faulty syringes, nothing to do with B12 - those pesky bubbles are just sometimes a nuisance 😀.

Don't let this put you off...or lose your confidence...just keep at it and try not to worry.


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Well I've just managed a good injection, getting better at pushing it in without shaking.ive been having to do alternate days for 4 so far as I had gotten really quite ill. I'm just going to keep this up until I feel really well this time .Thanks Foggyme &



Well done Peggylally66.

Hope you begin to feel better very soon 👍

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Well done! Keep at it! :)

I'm 11 weeks in and my hands still shake. :O :) Managed to nick a vessel few days ago and ended up with a nasty bruise. Then next day forgot to push all the air out of the syringe before injecting. Stuff happens. :) I sometimes still hesitate before a jab, getting up the courage to stick myself... It's all for a good cause ;)


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