Just joined this forum, quick background. After much misdiagnosis it was confirmed I had auto immuno chronic ulcerative colitis over 20 years age. Medication didn't work and too many STERIODS taken over 10 years i'v been on azathioprine . About 4 years back the gastro team were concerned my my blood results especially the megaloblasts. Tests were done and it was decided it was PA. the cause is either Autoimmune met aplastic strophic gastritis, or the drug is known over time to block or kill intrinsic factor.
I don't remember having the loading dose as I see recommended .i think a had a few b12 injections for 2 weeks then on to 3 monthly. I did ok at first. Due to costs etc, my care was handed back to the Gp, i'v had a few colitis setbacks no back on STERIODS , and continued the 3 monthly 1mg/ml, b12. It's been that way for the last 3 year. Of late I'm struggling one month before and 2 weeks after the recommended b12 dose. Coming to my question. My blood is and always macrocytosic large misshaped red blood cells. Now if my b12 was prescribed because of this anemia why is there no improvement ever. I believe as many that the dosage is insufficient . I and very symptomatic and now have pain in my long bones.