Still suffering from pernicious anemia symptoms

I don't have anaemia so it isn't something I'm particularly up on - anaemia is a potential symptom of B12 not a defining characteristic - and quite a lot of people these days - because there is folate etc in breakfast cereals, bread etc, tend not to show obvious signs of anaemia but are stil B12 deficient.

Just found this link that might help a bit

newhealthguide.org/High-Mch...

Your serum levels are high because you are getting B12 shots - one shot is about 800x the normal RDA so not surprising that your levels are high.

It sounds like you could be suffering from 'functional deficiency', ie the fact that your serum levels are high mean your body is trying to shut down the transfer mechanism so little if any is actually getting to your cells - it's only when you are getting so much in that your body can't actually create enough antibodies to shut the mechanism down that you get a benefit - so more frequent shots is, I think, the way to go ... but I'm not a medic or a biochemist or anything like that. I'm just going from my own personal experience. I get most of my B12 from nasal sprays which is a method of delivery that seems to work well for me. Even on the days when I have a shot I will supplement because I notice the symptoms coming back within 24 hours.

I use a mixture of hydroxo (which is the form in the UK where I live) and methyl because they seem to work better with different groups of symptoms

- hydroxo good for the psychiatric (depression, anxiety ... and it is an awfully long time since my levels got low enough for psychosis to be a factor - but even that was getting worse when I was on the normal regime here of one shot every 2-3 months)

- methyl good for neurological such as having a decent level of feeling in my left foot and not getting shooting pains from nerves being touched by tendons.

I tend to get through something like 3-5mg a day so don't think that I am actually using all of that up ... even if I am quite active ... or even losing all of it through urine (which is what the body does with B12 it can't use/store as B12 is water soluble). It wasn't until I started using B12 at this level that I actually stopped continuing to slide - balance went from struggling to walk to being quite happy at the top of a ladder pruning a grape-vine in matter of a few weeks ... and a few months later I realised that the depression and anxiety that I had had for decades had gone.

You may find that hydroxo is better for you than cyano - or if you had injectivle methyl that might work better ... or a nasal spray ... than the sublinguals. People vary a lot in how they respond to different formats and even different delivery methods and all you can really do is try - at least B12 isn't toxic so there is room to experiment.

Another thing to look it is where your folate (B9) levels are, as body needs folate to absorb and use B12.

My real battle at the moment is in balancing my B9 and B6 so I don't get bad headaches/migraines. Seem to have it right at the moment though

Hope you find solutions that work for you soon.

PS: I had a blood serum test back in December .. and B12 was off the scale but fortunately the lab had marked it as 'no action' so I didn't get grief from nurse or doctor ... not that it would really matter as I effectively treat myself these days but go back for shots just to keep it on my record.

Yes, I'm sure its possible and think that is what happened to me. My mother is the same - needs ridiculous levels of B12 to be okay. However, my aunt and brother - neither of whom have been formally diagnosed and haven't had injections - both manage very well using a nasal spray delivering 500mcg