Credit Julian Lo posted this on Lena's "Focused ultrasound for Parkinson's" Facebook page. (This was posted in response to a comment by Kawl Mie Pileaze who had recently been declined for PTT by Dr.J)
This is a good thread from Amy if you're interested in pursuing information. (This will be old news/old thread to many of you but I just stumbled across it. Read Amy's thread so as not to repeat the whole long discussion.)
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MBAnderson
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I was a super responder to IV glutathione initially - immediate improvement. I still take it orally - never stopped it so hard to tell how much it helps but I do know I still have morning benefits (wake up to mild symptoms off meds) five years + later
My initial reaction was almost as dramatic but I started l dopa about a week after which also improved my symptoms so my other injections weren't as dramatic because my bad was not as bad.
JAN, good to hear from you. I hope you'll visit us more often.
I look forward to your additional information. I do not doubt the video is authentic because like everything else, it may work real well for some and not at all for others. And, like so many other things, the relief is probably not permanent.
How have you been? How is life in Zürich? Are you on lockdown? Do the Swiss people cope with this pretty good? Have you been able to keep up your practice?
There have been a lot of doubts. The main one being that Dr P has not spent the last 20 years successfully providing this therapy for his patients a la dr constantini but instead focused on making money from gluten avoidance publications.
I meant it for the thread - since it was your post, I guess I meant it for you.
Nobody needed to mention Perlmutter. He's the guy in the video demonstrating an awesome benefit from glutathione injection.
The video dates from 2010 at the latest, and chum Perlmutter apparently started using the therapy in 1998. It's very old news, but nobody I am aware of, including Perlmutter, is running clinics offering this for the benefit of patients in the way Dr C did with his Thiamine therapy.
Richard, thank you, thank you. I did not know that was Perlmutter in the video. I'm not a fan. I scratched him off my list of health gurus several years ago. I minimize my intake of gluten, though, but not because of his advice.
I think the main concern is it was 20 years ago, and...nothing. I'm not aware this is an ongoing treatment in his or anybody elses clinic. I started to investigate it for my Dad, but IM glutathione has to be kept chilled, and is only in the USA. Its not cheap.
So there was interest in other delivery methods. Ingested tablets are universally considered useless. Laurie Mischley carried out a proper clinical trial for intranasal glutathione, which found positive results - but no better than placebo
The more I looked, the more it was very exciting, but didn't work. And any apparant benefits were modest, open label, and therefore probably placebo.
As we know, our chum Perlmutter is keen on self promotion, and makes questionable claims about numerous "alternative" health ideas.
"What about the “incredible effectiveness” of the “glutathione miracle”? Perlmutter has been an enthusiastic proponent of this substance for over a decade. In one 2010 online video posted by “Protandim Anti Aging” — more on that product soon — Perlmutter treats an elderly Parkinson’s sufferer with glutathione, effecting a remarkable recovery. BrainRecovery.com describes similar successes, multiple patients reversing Parkinson’s and getting off of medication after following Perlmutter’s “Parkinson’s protocol,” a combination of intravenous glutathione and supplements (available for purchase on his website).
These case studies raise an obvious question: If glutathione injection is such a miracle procedure, why hasn’t the protocol been more widely adopted? Perlmutter’s answer points to the profit-driven influence of Big Pharma: “Glutathione … cannot be owned exclusively by any particular pharmaceutical company and therefore won’t find its way to the highly influential advertising sections of the medical journals.”
Sure, maybe. Or it could be that doctors don’t prescribe intravenous glutathione for Parkinson’s because it doesn’t work. And they know it doesn’t work thanks, in part, to work done by a man named … David Perlmutter. In 2009, he collaborated on a randomized, double-blind study of intravenous glutathione for Parkinson’s. The results are clearly stated in the study’s conclusion: “We did not observe a significant improvement in parkinsonian signs and symptoms in the glutathione group when compared with the placebo group.” Based on these results, the National Parkinson Foundation put out a strongly worded statement about intravenous glutathione: “First, there is a lack of evidence it actually works; second, the therapy requires an intravenous line which has both short and long term risks; and finally, insurance does not cover the costs of this therapy. .. Patients should beware of any medical practices offering a fee for glutathione treatment of Parkinson’s disease.”
Once the glutathione study was finished, Perlmutter had various opportunities to disclose its results. Yet in 2009, shortly before the study was published, he told fellow celebrity doctor Andrew Weil that the treatment was “quite effective.”
It’s possible that Perlmutter just didn’t understand the results of the study, or perhaps he disagreed with the statistical analysis of his co-authors. The responsible thing to do, then, would be to acknowledge the study’s conclusion, state his dissent, and admit that it did not replicate the miraculous 80-90 percent effectiveness he claimed to have achieved in his clinic.
But he does no such thing. Instead, in his 2011 book Power Up Your Brain, Perlmutter doubles down on glutathione — “we shout the praises of glutathione,” he writes — not just as a treatment for Parkinson’s, but also for fibromyalgia, cancer, and the common cold. As evidence, Perlmutter cites a series of outdated studies but never once mentions the double-blinded study in which he himself participated (and no, there’s no solid evidence of glutathione’s efficacy in treating those other conditions, either)."
Hubby received glut injections from an integrative doctor not covered by any insurance. To visit the doctor costs $275 then $75 for the IV injection. One hour drive to office. Seemed to give him energy. Needed at least a quarterly visit with doctor to insure all blood work numbers were good.
He's back to having difficulty walking - starting and walking over thresholds or change in floor coverings (rugs to bare floors for instance). Would IV glut help? Not sure. Is it worth the travel time and costs? Not sure.
"Had a very disappointing phone call 10 hours ago with Dr. J. He was really thoughtful, kind and offered helpful advice though. Most of the 25 minute conversation was Dr. Jeanmonod trying to have me understand why he couldn't commit to helping my dad. (Yes, it was difficult for me to accept, I really wanted it to work!)
He said that my dad's form of parkinson's is really difficult to treat with any surgery, and that we might be disappointed to have him undergo the FUS and see that he still has gait freezing (one of his biggest problems is freezing). He also said that with my dad's kind of rigidity / gait freezing pd, he likes to have several follow-up appointments, and work on the emotional and psychological side, which would obviously be difficult to do since we don't live in Switzerland.
Dr. J recommended LSVT and most of all, doing intense psycho-emotional therapy. He said that in his experience, deep anxiety cannot be ruled out as a major player in my dad's form of parkinson's.
I asked if we could do LSVT and psycho-emotional therapy over here in Canada, and then check back in 6 months and he said that this could be a possibility.
So not completely ruled out, but Dr. Jeanmonod wanted to be really honest (which we really appreciated).
I was a bit disappointed by the news in the moment and forgot to ask other questions on the phone. After the call I sent an email and asked if the surgery would still help with my dad's dystonia, dyskinesia and bradykenesia... I'll see what he says, but either way, no FUS for my dad for now..."
Hi, thank you for the video on glutathione, my Wife has Parkinson’s and her symptoms are very similar to those in the video, would you know where the treatment was carried out.
I think we should all cool our jets on this as Winnie the Pooh and JANVAN (both doctors) and astute and knowledgeable PD researchers think there is nothing here, although, there are some on this thread (Lena) who say it has worked very well for them -- so I am not going to delete the thread, whereas, otherwise I would.
If something works good for one person, it may work for others and that is reason enough to leave the thread.
I got my IV injection from Dr. Mischley's intern and from the reaction I got from the staff and Dr. Evans that day I think my super response was highly unusual. I got the feeling it was rare to see someone have that amazing a response (this in a clinic which treats mainly pwp). So I think super responders are few and far between.
In 2017 right after PD diagnosis I went to a local ND and received IV glutathione “push”, a couple of times. They were expensive and I noticed no improvement in my symptoms. I do continue to take daily NAC to try to boost glutathione levels, with indeterminate results. Aside from Sinemet I’ve experienced the most symptom relief with Thiamine IM injections.
which reminded me I had some Liposomal Glutathione in the fridge, so I immediately got up and sprayed some into my mouth. Only just sat down and read this so I am taking it as a message and will stick to the once a day directions.
In Dr Mischley's latest lessons on PD she encourages use of Glutathione and how important it is. Dr Kharazzin also encourages use of Glutathione. My Dr has been adamant that I get enough glutathione, I may not have had a miraculous reaction to it but I have seen enough evidence to think it a priority to repress the progression of PD.
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