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Parkinson's Movement
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Glutathione Injections

Anyone taking Glutathione (GSH) injections? Outcome?

2. Research inconclusive but it seems to slow progression even though symptoms may persist. See next entry w Links

3. My psychiatrist writes my Rx. Not my Neurologist. My neurologist is a MDS with conservative views. I Skype w Laurie Mischley RD MPH ND - she advises the use of GSH intranasally. I seem to have Army of consultants —including you, my esteemed HU Committee!

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Are the injections painful? I was looking for those a while back amd got sidetracked. My husband now takes 50 mg Thiamine injections but they are quite painful. He doesnt voice how they hurt but nurse says probably it burns. Do u

have any exoerience with that, by any chance?

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Yes. Concentrated Glutathione burns me at >20 units. If you dilute w sterile water it can eliminate burn~I am told.

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That's interesting. Do u

know how much to dilute . There must be,a ratio, right? Was this a Healthcare Professional that told you? Iam interested in finding out where to get it. Can u help ?THANK U!

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Get a prescription and take it to a compounding pharmacy (google one in your region). Mine is a few states away and shipping on ice is expensive.

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I'm taking NAC to help body make glutathione. So far my decline is slow but very early days. Injections were recommended by my integrative GP but only available in beauty salons, so I gave it a miss.

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Good approach!

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Hi Amy, what do you mean by I see her too. Where would you get the intranasal glutathione? I was making my own for a while, using distilled water spray bottle and glutathione. I did not see any difference. Different places on eBay and Amazon sell the nasal spray. Looking forward to your answer. Mary

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Hi Mary,

I'm sure Amy will answer, too. Dr. Mischley prescribes a compounded version of intranasal glutathione that comes from a Compounding pharmacy in Seattle. It's been several years since I used it, but they ship it on ice, so I don't think it's the same as what is available online, but things may have changed in the past four years.

Julie

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I think it's a way bigger dosage, then what you can buy. Also my movement specialist in Spokane Washington is dr. Jason aldred MD. When I first saw him he told me that he went to school with doctor Mischley. She was getting such fabulous results that that's when I decided to mix my own. Mary

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Julie grace, why did you slide off the Glutathione? Isn’t it a lifestyle /lifelong commitment for cellular health? Did you have lab results verify your levels and if so, did they really matter since we ultimately want Glutathione in the brain (not the blood), which is not easily measurable —while we are alive:/

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I went off meds for a year and was too debilitated to deal with the nasal spray. I took an oral version for a while but the data on the efficacy said it was limited and I chose not to continue.

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You are ok now, though, I hope? What is your current success attributed to if you have dropped GSH? The intranasal compounds, if quality made, are worthwhile per Mischley studies with MRI load test results. I’m still researching...

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Laurie Mischley ND is in Seattle- google her for info on Skype sessions. She might write your Rx! She advises intranasal Glutathione over injections .

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Archway Apothecary in Covington LA will also fill a prescription from another doctor. In my case, my psychiatrist wrote my Rx after Dr Mischley recommended it to me.

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Than you Mary

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What was the cost?

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My wife used to see a neurologist and internal medicine doctor every month in Saku City, Japan near Nagano, Japan who used traditional medicine to treat Parkinson's disease along with other diseases. Part if th e treatment were glutathione intravenous administered, acupuncture and moxicupping as part of the treatment. She always moved smoother after this great and seemed to have more energy after each treatment. We currently live in Hawaii where she only gets treated with standard protocol medicine and acupuncture periodically. We will be moving back to Japan so that she can resume the previous treatment modality.

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I tried glutathione injections a couple of years ago and they did not seem to help. I had 3 injections a week for about 3 weeks. My Doctor at that time said if I did not see an improvement by then they probably would not work for me so I stopped having them. They were also expensive. They could work for others might be worth trying.

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I had similar experience. IV GTE did not help me. I now take NAC 2x daily.

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Meant IV GSH

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When first diagnosed, my husband tried the cream, the nasal spray and also the injections with our DO. With another MD, he also tried the liposomal glutathione. Can't say it did much, although we currently have the liposomal which he has used off and on. He's on B1 right now so we just wanted to see how that worked before adding the liposomal glutathione back in. And he has also used NAC with not much effect. BUT ... my husband is the poster child for everything that should work but doesn't :-(.

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Then he and my husband must be related😊

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There is also some published research on intranasal glutathione. Easier dosage form.

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Mischley advises Intranasal over injection ...

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I am having a weekly im injection of b1 and glutathion at the same time and together. After 8 months don t see much results yet.

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Does it burn and do u mean they are mixed in same injection?

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They are mixed in the same injection and it burns a little

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What dosage of each?

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Hi Marcet, are you in touch with Dr C. Regularly?

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No i am not. Why ?

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He'd give you some direction on the dosage of b1 for better results, as per peoples experiences here.

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Who is supplying / administering the injections? My doctor can't find anyone (hospitals, etc.) to get the product and administer.

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My family physician recommended replacing my bi monthly glut. injections with NAC, which is the subject of a late stage Parkinsons study at Mass General/Harvard Med.

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Status?

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NAC is a precursor to Glutathione. If we can get Glutathione to cross the BBB (IV, injections, possibly via intranasal ) why back peddle to NAC? I am over simplifying the science to some extent... but seeking the same answers as you.

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My neurologist is trying to find someone/somewhere to administer IV Glutathione which was at my request, not his. Neurologist listens to me but he doesn't come up with suggestions on trying different things on his own (and doesn't encourage or discourage vitamins, supplements, etc.).

The only place I could find on my own is my former integrative dr (for my lyme disease) who can administer iv glut. However, costs about $375 to see doctor and $65 for each iv glut - all out of pocket as they are not associated with any insurances.

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You can administer injections yourself ...

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Isn't getting the Glutathione 20 units a hassle? Understand its sent on ice ...

Need to find a good suppliert?

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Yes-ice. Archway Apothecary sends it 2-d air from LA.

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In addition oral acetylglutathione holds promise. Unlike glutathione it is more stable in gut. A novel encapsulated form called safe cell is available from a company TessMed. I use intranasal and safe cell.

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Thank you, I'll check into this

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Intranasal = reputed better compliance over injections. After my loading phase, Dr Laiurie Mischley, RD, MPH, ND recommends intranasal. Her phD thesis is on intranasal GSH. I wanted to start on injections- so I got the Rx from my progressive Psychiatrist who also injects / we’re sorta hard core...

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I am injecting Glutathione 20 Units subcutaneously/d and recently found to have high levels in blood: perhaps it is not crossing into the "brain" or it simply co-exists and/or is getting processed as I am in the loading phase. Seeking knowledge. Will address w my prescribing physician tomorrow. Meanwhile: do any of you have hunches: sunvox easilly jimcaster bassofspades, others?

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Right. It doesn't cross the bbb. You need to take bonded cysteine, like that which is found in whey protein isolate, such as inmunocal or immunocal platinum. I use Muscle Food or Promix brand. From what i learned the glutathione injections last a half hour when dr perlmutter does it on YouTube.

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I have to defer to Sunvox, Easilly, and Bass of Spades. I'm a semi-retired small town real estate lawyer. If you have a question regarding a legal description, I'm all in. Otherwise, all I know is what google or HealthUnlocked tells me. 😊

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I think that since glutathione has the bioavailability issue, it's viability is currently the issue to work around, a practical and affordable way to get enough to the brain and wherever else it is needed.

NAC is always mentioned as a readily available and an inexpensive precursor, but studies do not seem strong toward that end. Just guessing, I would say NAC might be glutathione sparing because of its own antioxidant activity and so it is good from that point of view. I imagine ground clove powder might be similar in this respect because of its very potent antioxidant activity and modest glutathione increasing effects plus anti-inflammatory qualities! In terms of other potential glutathione precursors, I would think some probiotics would qualify and I am a fan of probiotics, prebiotics, synbiotics and most fermented foods as I'm sure you have already guessed from my probiotic post and my post about mannitol.

Two major contributing factors to PD and many other disease states are excess reactive oxygen species and other oxidative stress factors as well as inflammation. These two components can feed off of each other in a vicious cycle. Probiotics (+) have shown potential in the effort to break the cycle by working against both, but it is also well established that PWPs have a perturbed gut biome that generates both in excess and I tend to lean toward the idea that probiotics et al can definitely help to repair gut damage and help return the gut biome toward normalcy. So you have increased glutathione production, anti-inflammatory activity, neutralization of oxidatative stress, gut repair, improved insulin sensitivity, and many other biological activities such as increased butyrate production, HDAC inhibition and increased hydrogen sulfide production to name only a few of the effects compared to glutathione enhancement which increases this potent antioxidant in a somewhat unnatural way. Well, you did ask!

If I had a limited amount of research money for PD research, I would probably spend a good portion of it on fecal transplant research, because I believe that that would be the cheapest way to find out quickly if it can work as well or better in humans as it does in mice models of PD.

When they give mice that have no immune system the gut bacteria from mice with PD symptoms, they get PD symptoms too. When they give these mice the gut bacteria from PD positive people they get PD too. When they give these mice the bacteria from healthy humans, they do not get PD symptoms. There are several more steps needed in order to see how this might play out in humans, but so far, not done.

Art

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Good stuff!

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Great advise Art, Ground clove powder and the biotics, natural as possible is the best way to go. Thank you

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nature.com/articles/npjpark...

Intranasal Glutathione’s effectiveness in “Central Nervous System uptake of intranasal Glutathione in PD” - LK Mischley, ND

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Mischley’s pharmacist produces a high quality unique formula which is costly (~$350/ month). Injections, on the other hand, can be 1/3 the price but there’s a trade off (effectiveness)?

?

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Look into inmunocal platinum. I cant remember if it's 3000 or 30,000 studies that have been done on the stuff. Its clinically proven to enhance glutathione with tripeptide bonded cysteine. Its not cheap but it probably costs less than injections. And its listed in the pdr so theres a chance insurance may cover it. I used it for 3 months, double doses, myself. Had great results.

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Ok

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bass,

Why did you stop taking it?

Art

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I stopped taking it because i couldn't afford it anymore. But...i figured out the formula and now i make my own version of it. Basically undenatred grass fed whey protein isolate with creatine and minerals. I dont know if im getting the tripeptide bonded cysteine but i still feel good using it long term. Ive been taking it most every day for a year and i consider it as essential as my thiamine and my amino acid protocol. A trusted dr i know who has a phd in nutritional medicine turned me on to inmunocal when i was at my lowest. He said guaranteed id feel better in 3 months. Within 3 days i was convinced, its that good! Add to this organic nutrition for extra credit.

For my next project im learning about autophagy and how it takes the misfolded proteins that form amyloid plaques and recycles them into good quality amino acids. Stay tuned!

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bass,

What benefits do you think you are getting from it?

Art

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Art, here is my list of benefits, there may be more...

more energy, very noticeable

immune system support

decreased brain fog, improved memory and cognition

increased lean muscle mass

improved sleep

improved liver function and detoxification

improved skin

improved athletic performance, strength

decreased fatigue

faster recovery after workout - immediate!

reduced effects of oxidative stress

reduced inflammation

Im 49 and people say I look 29

reduced risk of cancer, heart disease, diabetes

respiratory improvement

improved eye health

smoother joints

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' Im 49 and people say I look 29 '

Or it may be that playing the bass just makes you ageless! 😊

' smoother joints '

Yeah, I just hate it when they aren't tight and have air pockets in them! 😜😜😜

Art

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Oh. My. GOD THATS FUNNY!!!!😜

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I suppose you can smoke a glutathione laced doob?

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I can just see everybody gathering around you every time you exhale.....for their share of the glutathione of course!

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Me? Nah! I dont smoke joints for real. But u cant get enough of glutathione!

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I was looking into starting on whey protein but then came across some information by Russel Blaylock, MD (neurosurgeon) whose both parents had PD and he warns against using anything containing glutamate which is excitotoxin. He gives a list of 30 products containing glutamate in his book Prescriptions for Natural Health and one of those is "whey protein concentrate, isolate or extract". Since I react to MSG which is a common additive and contains glutamate, I am kind of concerned about trying whey protein. Would appreciate your opinion!

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my opinion is try it and if it doesnt make you feel noticeably better you can always stop using it. I highly HIGHLY recommend it! I consider it essential to my regimen, (and I drastically stripped down my regimen).

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Thanks!

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My dr told me to give it a 3 month try. That is what i reccomend for you. But if you feel worse or have an adverse reaction, then stop. I dont expect you to have any adverse effects because all it is is the same thing as mother's milk. BCAAs, immunoglobulins and cytokines.

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Did you use a pack a day? Seems to be around $10 a day!

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I used rwo packets a day. I got it on ebay for about $75 -$80 for 30 packets. I did this for 3 months then i figured out how to make my own version of inmunocal platinum with whey protein isolate and creatine plus minerals. I still take it every day. The difference i felt within the first few days was astonishing.

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Can you tell us your formula? I’m reluctant to shell out for the commercial brand which is very expensive in Australia.

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Sure. The main ingredients are

1.5 scoops undenatured grass fed cold pasturized whey protein isolate, such as Promix unflavored. 2 scoops on days i work out. 16g per scoop.

5g Creatine monohydrate

1 cup organic grass fed cow milk

1/4 cup Siggis yogurt drink (low sugar)

Optional: any of the following-

1 cup organic kale

1/2 cup mixed organic berries

1/2 organic banana

1/2 cup coffee (i use mannitol and heavy cream too)

1 tbsp organic coconut oil

Blend in a smoothie blender. Or shake well. I use a Ninja. Eat a multivitamin mineral tablet with that.

If you have kidney problems, skip the creatine. Creatine probably shouldn't be used every day. I use it 4-5 days a week.

You may substitute water for the milk and yogurt. Chocolate syrup is fun to add as a treat once in a while!

There you go! My secret formula!

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this is interesting on glutathione and exercise :

ncbi.nlm.nih.gov/pmc/articl...

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Husband gets IV glutathione injections from an integrative doctor - meaning we pay full price. Neurologist couldn't find anyone to "GET" the iv stuff never mind do the injection.

I don't believe anything reverses PD. Hubby gets the glut injections to increase his energy. Usually lasts about 5-6 days then seems to wear off. However, this energy has helped him realize he CAN do things, he CAN walk further than he thought - he just really needs to push himself. He's had about 8 shots so far. Will get several more then stop. Added turmeric and magnesium to his supplements. We'll also go back to acupuncture.

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