I am questioning the dosage of B1. Am I on the right track?

[bepo]

My husband has taken B1 for the last 3 months, along with his mucuna. We started at 2 grams, and have gradually lowered the dose of B1. He is now taking 200 mg 2xday. His tremor has slowed down from a 2-3 to a 1-2, and has even stopped completely at different times. When his symptoms got worse, we lowered the dose. Now with the 400 mg, he seems stable for 5 days. Do we wait for several months to see the best results?

[PeteW]

I find better results with benfotiamine as well which is also B1

[bepo in reply to PeteW]

Thank you.

[parkie13 in reply to PeteW]

Benfotiamine is fat-soluble vitamin. If it accumulates to excess it might take a while for it to go down.

[bepo in reply to parkie13]

Interesting. We prefer natural, non chemical remedies, but are always open.

[rescuema in reply to parkie13]

Benfotiamine is readily-absorbed and more bio-available than many other forms of B1, and especially great for peripheral/organ absorption than other forms. It has a low toxicity when taken as directed. Earlier studies indicated that it does not directly cross the BBB, but later studies demonstrated that it does benefit brain functions. I suspect it's because it restores compromised transketolase activity over time. For some, it's definitely worth a try.

ncbi.nlm.nih.gov/pubmed/203...

[parkie13 in reply to rescuema]

Before I even heard about thiamine HCL and Parkinson's use, I tried benfotiamine since I have diabetes 2. I kept on taking it three times the recommended dosage as was stated on the bottle. I got very high blood pressure, had no idea what it was from. It took for it between two and three weeks to go down. It happened more than one time since I resumed taking it. So then when I tried thiamine HCL and got high blood pressure I knew what it was from almost right away. I realize not everybody gets high blood pressure for thiamine HCL or benfotiamine, reading the comments on this site I think there's at least a couple of people that do.

[rescuema in reply to parkie13]

It'll depend on finding your methylation balance. The same symptom(s) can happen from intake of Tru Niagen (nicotinamide riboside) that so many recklessly rave about for increasing NAD+, but too much or too little of good things have serious consequences depending your status. B3 (including NR) in excess can also affect serotonin and dopamine level leading to mood/brain disorders among other serious side effects (read Amazon reviews), and it tends to deplete methyl donors, great for some schizophrenics (or overmethylators) but harmful for those with depressed NT activities. Although B1 raised your BP, it'll have an opposite effect on someone else depending on the cause of the imbalance.

[parkie13 in reply to rescuema]

You are so right. Tru niagen did the same thing to me, gave me high blood pressure also. So what is your recommendation what should I do?

[rescuema in reply to parkie13]

Get your homocysteine level (SAM/SAH is better but not a lot of labs have capacity) tested (suspect b6, b9, b12 absorbtion), and find your histamine level (for methylation status, although not foolproof without genetic test). Also suspect Zinc and D3 deficiencies, etc. Without running a blood panel, it's not easy to blindly recommend what to do specifically.

For that, you'll need to find a physician who is trained in nutrient therapy to support your needs. See if you can locate one near you with decent reviews.

walshinstitute.org/clinical...

Alternately, learn the applicable basics by reading a few books, and possibly grasp the missing link based on your nutrient intake.

amazon.com/Nutrient-Power-H...

amazon.com/Dirty-Genes-Brea...

[rescuema]

Yes, keep at the dosage where you don't see worsening of symptoms. Progress may take months. It's all about finding the balance and providing the nutritional support your neurons need. See the below post for more detail.

healthunlocked.com/parkinso...?

[bepo in reply to rescuema]

Thank you! All part of the learning process

[rescuema in reply to bepo]

Never stop learning.

[bepo in reply to rescuema]

Always learning

[bepo in reply to rescuema]

Thanks much!