Small Study Finds CoQ10 Effective For Relieving Orthostatic Hypotension, Including OH due to Multiple System Atrophy

[park_bear]

This is a small study - only 7 people. However, P = .007 shows the results in this group were highly significant. I put more stock in a study like this than a big study that barely meets P <.05.

amjmed.com/article/S0002-93...

Abstract

Background

Multiple-system atrophy is a neurologic disorder characterized by orthostatic hypotension, Parkinsonian signs, and cerebellar signs. Mutations in COQ2, an enzyme involved in coenzyme Q10 synthesis, were recently associated with familial and sporadic cases of multiple-system atrophy. I hypothesized that people with orthostatic hypotension with or without other symptoms of multiple-system atrophy might benefit from oral coenzyme Q10 administration.

Methods

Seven patients with symptomatic orthostatic hypotension were treated in an unrandomized manner with 257 ± 37 mg coenzyme Q10 daily for 10 ± 3 months.

Results

Before starting coenzyme Q10, patients' systolic blood pressure fell 30 ± 4 mm Hg upon standing from a sitting position. After treatment with coenzyme Q10, their systolic blood pressure decreased 7 ± 5 mm Hg upon standing from a sitting position (P = .007 for change in systolic blood pressure decrease by paired t test).

-----------

Note that the threshold for a finding of orthostatic hypotension is a fall in systolic blood pressure of 20 points or more. So at the end of the study these patients would be regarded as not having orthostatic hypotension.

[MarionP]

That's very interesting, worth a "clinical" follow-up study.

[ddmagee1]

Very interesting!! Thanks for sharing this, park bear! I've decided COQ10 is for me!

[PDGal4]

Thanks for posting. I take 600 mg COQ10 daily and do have low blood pressure/orthostatic hypotension. Nice to know it's helping that too. I take it as I believe it helps slow progression for Parkinson's.

[KERRINGTON]

I've taken 100 - 200 mg 4x a week for energy and notice when I'm off it. I experience a lot more hypostatic episodes. Originally started at 10 -50 mg. I've cautiusly taken it since 1996, well before my PD, for stamnia. It is very powerful.

[JBOVERT]

hi park I am taking 600 mg Dailey of ubiquinal which I take300mg in the morning and 300 mg @ night just before bed

the reason I take it in the evening is because I take 20 mg of rosuvastsatin (sic) at night just before I go to bed