GDNF, Thiamine cell repair. Heavy stuff!

Found the attached which I think pulls together a number of recent threads. I say think because it’s very specialised.

I am going to study it but if there’s an expert who can digest/explain it please help?!

jneurosci.org/content/18/8/...

[Gioc]

This GDNF was used for retinitis pigmentosa in Italy but I have not heard of it anymore, could thiamine do something for retinitis?

[Hidden]

Possibly. This paper is basic research and a long way from clinical application.

It’s just part of my attempt to understand why Thiamine might be working and how other contributors threads could tie in

[danfitz in reply to Hidden]

This IS a tough read. I hope someone posts a translation.

[park_bear]

"GDNF therefore may be useful in the treatment of peripheral neuropathies and may protect peripheral neurons that are refractory to neurotrophin treatment."

This applies to neurons outside the brain - talking about neurons with long axons, the kind of neurons that get signals from the spinal cord to the muscles.

[Gioc in reply to park_bear]

I see, but seem it not work on RP retinite pigmentosa. But is possible b1 working?

[park_bear in reply to Gioc]

I was merely speaking to the results of the particular study that was linked to. I have not studied this broader question.

[Gioc in reply to park_bear]

Yes I know, thank you Park_bear.

[Hidden in reply to park_bear]

No criticism intended

[Gioc in reply to Hidden]

exactly.

[Hidden]

True in this paper. But at the biochemical level it may also apply to all neurones which use GDNF. See references 4 and 7 They all use Thiamine. It think it’s worth discussing in the absence of any specific research

[Gioc in reply to Hidden]

Having followed the use of the GNDF that was co discovered by the Italian Nobel Prize winner Rita Levi Montalcini, I can tell you that there has been a lot of clamor about this here, but still there are few practical uses. An eye drop based on GNDF was tested and there were many hopes as always for the RP, but then not if it is more talked about. While I was wondering if the same b1 could work, because it seems to follow the same pattern of parkinson's when it is used.

[Hidden in reply to Gioc]

A pattern is beginning to emerge at least in my mind Thiamine, Exercise, The biome and Ibogaine are all linked to cell repair via GDNF...thoughts?

[Gioc in reply to Hidden]

If you want my non-authoritative opinion: no. Observing the obvious, thiamine restores nerve cells favoring the processes of energy creation of the mitochondria and enough is enough to prevent them from dying.

[danfitz in reply to Hidden]

Yes. I observe the same pattern. I just wish I could figure out the best way to exploit it.