Glutathione intraveinously

[Boyce3600]

Does anyone do this; have you found it helpful and if so how has it helped? Also how does one determine proper dosage, how do you access it and what is the cost?

Thank you!

[reikifriend]

I have heard this is an effective treatment from someone from China. Not sure of dosage or application though.

[JMDean]

I'm under the understanding that this is been completely debunked. There doesn't appear to be any benefit from an intravenous formulation of this. The national Parkinson's foundation put a little something about a randomized, double blinded control study that was performed on this some years back .

parkinson.org/find-help/blo...

Glutathione continues to be an area of interest but this particular formulation doesn't seem to be beneficial and I believe the standard practice is to recommend against it

[PDDBSwife]

My hubby did this back in 2002 in the US. He was 2 years into PD and not yet on L-Dopa compounds. Upshot is he had many (dozens) of IV pushes (maybe a standard-sized fluids bag) followed by a trip to Philly to continue these and supplement with a course of Phosphatidylcholine IV pushes. After about 6 months we were broke - didn't make one damn bit of difference.

That said, it's crossing the blood/brain barrier that's the problem: if glutathione has merit (which it likely does), it the BBB and its wont to 'alter' or bar substances...this is greatest challenge to any drug therapy.

Good luck!

[AmyLindy in reply to PDDBSwife]

Sorry u went broke & thanks for heads up to all here

[Jmwg45]

Was this glutathione itself being put in? This is known to be broken down in the body thus not reaching the brain

I know research is ongoing for N-acetylcysteine (NAC) which from what research I've looked at produces glutathione which crosses the blood brain barrier.

A couple of articles:

cureparkinsons.org.uk/the-n...

ncbi.nlm.nih.gov/m/pubmed/2...

[park_bear in reply to Jmwg45]

Yes. NAC, this: journals.plos.org/plosone/a...

[trishtheteacher]

I tried iv glutathione. In my experience, it wasn't worth the money. It did help me, but not enough to justify $500 a month. Now I use intranasal glutathione (spray) which you can purchase on Amazon.

[Donzim]

If you have low glutathione it will help your body do what glutathione does. It is poorly absorbed via the gut, hence the IV(and it must be an IV, not just a 'shot)'. My husband benefitted but the IVs were a problem. He got an arm port and later a chest port.

[Doodeet]

I believe there is a group on FB. Just enter key words in search bar. Some people have problems with it so you are smart to investigate.

[MBAnderson]

I agree with Jmwg45. There are lots and lots of data that show glutathione is a critically important amino acid and powerful antioxidant which is expensive and of little to no value when taken directly. NAC is an affordable precursor that crosses the BBB.

examine.com/supplements/glu...

Whenever the dose doesn't have to be precise, powder is less expensive.

250 grams, $20 from Bulk Supplements

bulksupplements.com/n-acety...

[Boyce3600 in reply to MBAnderson]

Did I understand you right.. that direct, i. e. through injection, does NOT help?

[MBAnderson in reply to Boyce3600]

I did not mean IV administration, I was meaning oral supplements.

[Kia17 in reply to MBAnderson]

Please can you tell me about your experiences with NAC?

[MBAnderson in reply to Kia17]

Like with everything else, I cannot attribute anything solely to NAC.

[rebtar]

Does anyone who has researched this have an idea if a) intranasal glutathione, or b) liposomal glutathione are forms that could reach the brain?

livonlabs.com/cgi-bin/start...

[MBAnderson in reply to rebtar]

glutathione.wellwise.org/ho...

Liposomal glutathione crosses the BBB and liposomal sublingual and intranasal dosing are better.

But, again, NAC is cheaper and crosses the BBB.

ncbi.nlm.nih.gov/pmc/articl...

[rebtar]

I remember reading, but can't remember where, that if mitochondrial function is compromised, then the process of conversion of NAC to glutathione is also compromised. Does this make any sense? I'm not a scientifically minded person, just trying to make sense of this to figure out what I need. Currently take NAC, but looking to see if there are better options.

[MBAnderson in reply to rebtar]

Have you looked into Curcumin and/or Mucuna Pruriens?

examine.com/supplements/cur...

[rebtar in reply to MBAnderson]

Yes, I take Curcumin, Thorne Meriva 500, total 1g per day. I've purchased mucuna (98%) but don't take yet, need to figure out how to start, I've followed Silvestrov's protocol but haven't put it together yet. Symptoms are still pretty mild. Not on any meds except rasagiline which I'll probably stop next neuro visit since it's had no symptomatic effect that I can tell.

[MBAnderson in reply to rebtar]

I think Meriva is for the gut and longvida for the brain/PD.

altprotein.com/top-four-tur...

[healthabc in reply to rebtar]

please point me back to Silvestrov's protocol? I can't find it- I am YOPD, tremor dominant.

[rebtar in reply to healthabc]

Scroll down for Silvestrov in the first link.

healthunlocked.com/parkinso...

This link is a caution about using EGCG.

healthunlocked.com/parkinso....

[Boyce3600 in reply to rebtar]

Wow, thank you. I always take note if what Silvestrov says. He is a brilluant source. Silvestrov, if you are reading, I have wondered what your occupation is would you mind sharing

[AmyLindy in reply to Boyce3600]

I appreciate Sivestrov as well!💪🏼

[rebtar]

Is longvida the brand name?

[MBAnderson]

No, it's a formulation. The link explains it. It's a good info link re Curcumin. Wish I could take it. Make sure you're not taking any drugs such as Nilotinib (which I am) that prolong the QT interval.

altprotein.com/top-four-tur...

[rebtar in reply to MBAnderson]

Thanks MB.

[healthabc]

Tried it, 6 months of IV's, n o difference except my veins gave way/ trauma. Had high hopes for it, was with phosphatydal choline. My tremor dominant pd still progressed. Very expensive.

[mj2dg]

I take both NAC and Jarrow Reduced Glutathione. I had been taking the NAC for a long time but found when I added the Glutathione (I take 2 capsules 1 AM and 1 Noon) after about 2 weeks my memory was starting to improve. I hadn't been able to remember anything from prior to 2006 in any great detail. After about 6 weeks on the glutathione I could remember many things from my past and had much better short term memory. I may be the exception but in my experience it works and it's a relatively cheap supplement so I will continue to take it.

[hanifab23]

please tell what brand and where you get it

[p-oui]

There are no other glutathione trials at this time because it is not proving to be more effective than placebo if done intranasally and there have been some issues with infusions. As an alternative to glutathione, NAC is being tested as it passes the blood brain barrier (best if injected).

journals.plos.org/plosone/a.... Intervention: IV NAC infusion: 50mg in 200ml of D5W over one hour 1 x per week Oral N-acetyl Cysteine - 1 600mg tablet 2 x per day (on days IV N-acetyl cysteine is not administered). Compared to controls, the patients receiving NAC had improvements of 4-9 percent in dopamine transporter binding and also had improvements in their UPDRS score of about 13 percent.

I am surprised NAC is not being delivered via infusion to PWP since they do glutathione injections for PWP. Here is what is required for NAC:

[Acetylcysteine is the nonproprietary name for the N-acetyl derivative of the naturally occurring amino acid, L-cysteine (N-acetyl-L-cysteine, NAC). Acetadote is supplied as a sterile solution in vials containing 200 mg/mL acetylcysteine. The pH of the solution ranges from 6.0 to 7.5. Acetadote contains the following inactive ingredients: 0.5 mg/mL disodium edetate, sodium hydroxide (used for pH adjustment), and Sterile Water for Injection, USP. Acetadote doses were prepared for each patient by a trained study nurse. The dose was 50mg/kg mixed into 200ml of D5W infused over approximately one hour 1x per week. Subjects took the 600mg NAC tablets 2x per day on the days that they did not receive the IV NAC.]

[Boyce3600 in reply to p-oui]

Thank you soooo much This is important info and I so appreciate your time and expertise!

[p-oui]

Thanks it takes a while to dig up this info, let me know if you go further with it!

[Boyce3600 in reply to p-oui]

You are SO right. And yes, I will let u know

[AmyLindy in reply to p-oui]

I also greatly appreciate the extra NAC details & reference,p-oui ! 👌🏻

[AmyLindy in reply to AmyLindy]

I found NAC life extension brand 200 mg tablets for approximately ~ $30/mo . Or if taking twice per day ( therapeutic dose by some references )~ $60 mo.

[sisterof]

I didn't see where it was posted already, but there is a glutathione lotion out now. I do not have PD (my brother does), but I need it for methylation efficiency. I get the lotion from the Xymogen website. Our family just couldn't hack the liposomal liquid. I know they have capsules too, but I think the lotion is easier because you can put it on anytime; not having to concern yourself with when you eat. It's pricey though. I think it will last me for quite sometime though. (We also take the NAC)

My family had our nutrigenomics done to see what mutations (SNPs) we had, etc. While I am pretty savvy about nutrition, I was unaware of the actual methylation process(es) our bodies undertake every second of every day. I hired a nutritionist experienced in evaluating our DNA data from 23andme. (we all did DNA testing many years ago for genealogy. We've done AncestryDNA, Family Tree DNA as well. I like them all as they all have their own strengths. There are many groups on Facebook who discuss DNA testing, gene mutations, etc. I can give you my nutritionist's link if you're interested and if that's allowed-- or you can email me.)

My brother has done DNA testing also and we are consulting with our nutritionist who has other PD clients. Having said all that, my main focus on this reply was about the glutathione lotion form.

[NRyan in reply to sisterof]

I am wondering if I can make my own glutathione lotion? I read glutathione breaks down quickly after being introduced to a liquid/lotion. It is best to mix it in and then apply immediately. I use coconut oil on my face and am going to add a little powdered Glutathione to see if it has any affect. Worth a try!

[AmyLindy in reply to sisterof]

Won’t the NAC At :

~1200-1500 mg/d get you to the glutathione benefit level already proven or researched to be effective?

[sisterof in reply to AmyLindy]

AmyLindy, was that question directed at me? I am not qualified to answer but it may depend on your GSH deficiency level, genetic mutations, general health, etc as to if you need both GSH and NAC if that is what you mean.

Here is something my nutritionist said back in Jan'18 about GSH and NAC: "Lately I have learned that we should not use GSH every day because the body will stop making it if we provide it all the time. I have started recommending GSH on, say MWF alternating with the precursor NAC on T-TH-Sat with Sunday off." I think that would go for PWP as well.

I also asked her about best-absorbed types -- "Best that I know is IV glutathione, then liposomal. Chris Shade at Quicksilver has a liposomal spray – <quicksilverlife.com/store/l... I like Seeking Health liposomal liquid. I do not know much about the liposomal soft gels. The lotion is next for absorption."

[AmyLindy in reply to sisterof]

Alternating GSH & NAC sounds practical. Currently, I take NAC on the advice of the M.D. that interpreted my DNA results. He did not mention Glutathione. However, I remain curious. Thanks for the info and references! Following.

[sisterof in reply to AmyLindy]

Please watch/listen to Dr. Ben Lynch (Seeking Health) about supplements and glutathione, what it is/does/when to take etc. You can find him easily on social media or his Seeking Health website videos.