This is an impressive Pharmaceutical from hops. I was wondering if anyone is taking it here?
I can only find Swansons brand but at the dosage I am taking it, its pricey. 90 caps of 10% Xanthohumol extract, ~ 20$ I got it from Amazon UK for 15 UK pounds / 90 caps.
Since one cap= 5mg Xanthohumol ( 10% ), I take 10 caps per day, 50mgs. Instructions on bottle say Take with a glass of water. No instructions about food. What can I assume from that ? Food or no food ? I take it with a fatty meal, but one time took it on empty stomach to see any difference. I don't see any side effects from it or benefit, but only gone through one bottle of 90 caps / 10per day.
One person I know is taking bulk powder 98% Xanthohumol 2 spoonfuls a day, that must be a LOT, but lost contact with them. He attributes it to going back to work.
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"xanthohumol is a game changing for me thanks to your old posts its really helped , i take it with water first thing in the Morning on empty stomach and i don't take any thing after it for one hour,the result i am getting is better than Nilotinib 150Mg , my medications working for longer hours and i have being able to reduce the sentiment dosage to the half, all my symptoms improved specially the cognitive ones and memory , i feel much better than 4 years back ...."
and then:
"Finally I got the right combination of supplements I think this is the best result I achieved until now .
Thanks to the great people of this forum , I think this combination will work for every one just you need to give it a six weeks time:
Mannitol 2 Tbs morning
S-methyl-l-cysteine 1-3 GMs 12 PM mixed with water or juice (dont take it with sinemet).
MTC oil 2 TBs at 1 PM (don't take it with sinemet).
Xanthohumol powder 98% one TS mixed with water at 8 pm
My dystonia gone and my dyskinesia gone and sinemet is working much better I started driving my car again and I m planning to go back to work again in September .
Who said that Parkinson's is irreversible ....... I don't believe that and I proved it .
I am much better than 5 years Back .
Many Thanks to silvestrov , park_bear and Prof. Daniel Sega."
I would second the Mannitol, MTC (coconut oil for me) and am full of optimism that there is a recipe out there which can slow the disease for everyone.
ITS a puzzle to me why more people in here are not on Xanthohumol.
IT seems THE supplement to take because it addresses the causative agent in PD A-Synuclein. All other drugs we use for PD have one target DOPAMINE, or the side effects that Dopamine drugs cause. Dopamine while very important in the brain function, its lack of it is the SYMPTOM and its replacement is only addressing symptoms of PD. A-Synuclein was discovered as the causative agent in PD in the 90's I think. Here's the latest study confirming that.
Maybe its the price, that causes Xanthohumol not to be used, or the availability . Big- Pharma products maybe very pricey, but when they say a certain amount is in a pill, it always IS. The FDA closes them down otherwise.
Is Swanson's Xanthohumol 5mg/cap like they say ? Or am I wasting my time and money ? Not sure.
While there are many questions on the exact mechanism A-synuclein causes PD there is nothing available that targets it. Nilotinib a chemo drug for cancer has the same mechanism of action like Xanthohumol, but the jury is still out, we know Nilotinib for PD since 2015 ! Still no answer if it works for PD. Novartis is charging 100K a year for it ! So even if approved how many PwPD can afford it?
<i>"Was reading this old post between you two and I found a thing interesting to me and would share my levity regarding the Swanson's supplement that you wrote of. "XanthoVital is produced in Germany by the world's leading experts in research and extraction." Germans are purists about food and drink, beer included, of course. Hops for making beer contains Xanthahumol. Germans are experts, of course, at hops and extracting processes." I'd say we could trust that the Swanson's product is a fine extract for our purposes. God bless us."</i>
So I would say it is worth it. If it worked for jaberalhd then it should work for you.
In part reads: "Here, we show that xanthohumol has in vitro activity against Bcr-Abl+ cells and clinical samples and retained its cytotoxicity when imatinib mesylate-resistant K562 cells were examined.
Imatinib was the first generation Bcr-Abl Tyrosine Kinase Inhibitor. Brand name Gleevec, was named by Time magazine "Man of the year" 2000 or about.
Resistance developed to Imatinib, and Nilotinib came about.
At least IN VITRO, Xanthohumol is acting like Nilotinib, but live organism have the nasty habitsof not obeying to In Vitro sometimes.
Xanthohumol is a LOT safer to try than Nilotinib. In desperation I was ready to try Nilotinib, but opted for Xanthohumol instead.
Are you still taking xanthohumol and, if so, do you still feel real positive about it helping? What brand have you settled on and what dose?
Except for the 1st 5 weeks of 2017, I've been taking nilotinib since 11-1-16. (I went in with the couple dozen people and had a compounding pharmacy in China make the stuff. (We then had a lab in the states certify its authenticity. We paid $10 a gram for it.) I was taking 95 mg twice a day for 2017, but 2 months ago went down to 125 mg day. My progression may have stabilized or I may be progressing very slowly, I can never be sure, I vacillate, but I take a lot of other stuff so I cannot attribute anything to nilotinib.
I've been in touch with 2 other people who were taking 150 mg a day, one for 15 months and the other for 20 months, but both quit several months ago saying they could not see any benefit, although one said he was going to resume because nothing else was working for him. Also, there is a participant on this forum with myeloid leukemia who is taking nilotinib and said it didn't do anything to stop or affect her PD.
I don't know how to reconcile our experience with the Georgetown study.
Two things, one I tried xanthohumol as one of my experiments in trying to clear psoriasis, but found no benefit at all after 10 bottles. It is a little pricey and the high dose doesn't help.
For the member that you know with myeloid leukemia, they might be interested in looking into colloidal silver nanoparticles. I have been reading about, making and using colloidal silver nanoparticles for years and though they are useful for many things, they seem to excel at neutralizing blood borne pathogens. I am not talking about the type of silver that causes argyria or blue gray skin from photo reaction with uv rays.
Thanks for the heads up about xanthohumol, which reminds me, once again, the pattern on HU is that once a week I read a post about something I've never heard of before that's working wonders for the poster and it launches me off into several hours or days of research and in the meantime a bunch of other posts appear giving it mixed reviews. HU is kind of a never ending cycle of tracking down each other's leads. The solution is the same one for consolidating information about thiamine, but with the same problem, i.e., a spreadsheet, which, unless there is some way to announce it, would get buried like all other posts.
I'm just thinking out loud -- gotta be a (better) way to organize the mountain of good information being collected here randomly.
I sent them an email about your read-only idea, but have not heard back. I'll start pestering them again.
Thanks for the info regarding the person with leukemia. I haven't located them yet, but I will soon enough and will cut and pace your material into a private message. (Maybe they'll read this post.)
What is the difference between liposomal and nanoparticles and since it neutralizes blood-borne pathogens, shouldn't we all be taking it as a prophylactic measure?
Really Art, if in addition to your other potions, you're dinking around converting things into nano-particles, what do we need clinical and re-purposing trials for anyway? We can just make a list of everything that's poorly absorbed and you can convert it into nanoparticles.
Marc
PS. Well, she's identified herself and talked about her leukemia a couple times in posts, so not I'm revealing anything. It's Becky.
For a long time I pretty much had to experiment as a means of treating myself and it has become a life long habit now. I used to be much more aggressive when my psoriasis was life threatening, but now that it is controlled, I have dialed it way back, thankfully!
I am not aware of any liposomal forms of colloidal silver and I think that if it were available, the coating might degrade the effectiveness. Ionic silver is much smaller than silver nanoparticles and is actually too small because the tiny ionic silver will easily enter cells, but the problem is that once it is inside the cells it binds with other particles such as selenium or sulfur and is permanently sequestered there because it is now too large to exit the cell. this creates silver selenide or silver sulphide which is neither wanted or desirable If those cells happen to be near the skin surface, there can be a photo reaction with uv rays and this can create a photo reaction that results in the cells turning a bluish gray color in a somewhat similar fashion to the old instant Polaroid picture film or argyria as seen on Paul Karason who drank his home brew of what was likely some form of silver with a high ionic content and he probably used large amounts of sodium chloride in his process.
Silver nanoparticles on the other hand are much larger than ionic silver and as such can not enter cells in the same way and while it is true that nanoparticles can release ionic silver, this mainly occurs when the particle comes in actual contact with a pathogen or extremely close proximity and then releases ions which neutralize the pathogen through at least one process.
From studies, colloidal silver nanoparticles have a narrow optimum size range that is most effective at pathogen neutralizing in humans and animals while being less detrimental to normal human cells. Many retail manufacturers claim that they have the smallest particle size like this is a good thing, but that is just advertising hype. Particles with a size below 10 nm are more destructive to human cells and more so the closer they get to 1 nm or smaller. Silver nanoparticles lose pathogen neutralizing efficacy the further they climb above 20 nm. The optimum particle size range for maximum pathogen neutralizing capability with minimum negative impact on normal cells is in the 12 to 20 nm range. These particles will normally appear as a medium yellow color (due to plasmon resonance) if the silver is at the 20 parts per million (PPM) area. As the parts per million increases the silver will go from this baby shampoo color of yellow toward a brown color. As the parts per million increase toward 200 or higher, the color looks similar to black coffee. The drawback to the increased PPM size is that the particles will have to be coated with some type of stabilizing agent to keep the particles in suspension and prevent agglomeration where the particles start to join together until they become so large that they fall out of suspension and become ineffective at pathogen neutralizing. All silver nanoparticles are colloidal silver, but not all colloidal silver is nanoparticles. Colloidal silver covers the range from 1 to 500 nm. Silver nanoparticles only cover the range from 1 to 100 nm.
Regarding using it as a prophylactic, probably better to think of it as an antiviral or antibiotic, use only to actually treat a pathogen or when using certain antibiotics because it can have synergy with some antibiotics and it can also revive an antibiotic that you have become resistant to! There are studies to confirm this!
Marc, I can tell you a little bit about silver nanoparticles, but I can tell you nothing about spreadsheets! 😜
Why do you suppose the stuff isn't sold commercially for colds and flu or for a range of other bacteria and viruses? (Seems like you could be an overnight millionaire!)
I don't know anything about myeloid leukemia, but why would a pathogens neutralizer help that?
Since psoriasis is an autoimmune disease and either Parkinson's is also or it's at least a major part of the problem, might your regimen help with PD?
Actually it is, but most retail products are ionic silver and you will know this because they are sold in brown or blue bottles to prevent them from partially reducing to colloidal silver through exposure to uv light. Ionic silver is effective also, but is harder on normal human cells and comes with greater potential for argyria, but to be fair, you would have to consume very large quantities daily for a long time for that to happen. I think the reason that most manufacturers make and sell ionic silver instead of colloidal silver nanoparticles is because it is cheaper to make. The problem is that all of these ionic silver manufacturers call their products colloidal silver when technically, that is incorrect and it can be very confusing for the end user.
As to being used for colds or flu, many people will say that they cured their cold over night using CS, but when you consider that colloidal silver works mainly in the blood because that is where it travels and it actually has to come in contact with a pathogen in order to neutralize it, it doesn't make much sense that it will have much if any effect on the respiratory system and in fact I have actually caught a cold during periods when I have been drinking large amounts of CS and the silver did not seem to have any effect on the cold. However, in order to give CS a chance to interact with the offending pathogen for direct contact, I have used the CS via a ultrasonic humidifier and been able to rid myself of a cold in as little as a day and a half if I catch it right away. I use the ultrasonic humidifier instead of a nebulizer because the ultrasonic humidifier simply delivers more CS in a given period of time compared to a nebulizer. You may think that this is a trivial difference between the two, but when you consider that the actual surface area of the lungs is equivalent to approximately the area of a tennis court and keeping in mind that the silver nanoparticle has to come in direct contact with the pathogen in order to neutralize it, you can see that it is important to deliver enough CS.
Flu can be a little tougher because it manifests in more areas of the body and CS does not go everywhere in the body, so if it can't come in contact with the pathogen, it can not neutralize it.
It really takes a bit of time to understand what CS is likely to help or not help.
As to why it may be effective against leukemia and other cancers, you only have to consider how chemotherapy generates massive amounts of reactive oxygen species (ROS). Cancer cells are relatively unstable compared to normal cells and are more susceptible to the damaging effects of ROS than normal cells. CS can generate ROS in lesser amounts than chemo and CS may be attracted to cancer cells due to surface charges which may add targeting effects, but I believe that is only speculation and not yet proven. It is not yet known the exact method of action, but this is one possible way. With chemo, the idea is that the instability of the cancers cells will cause them to die before the stable human cells will, but you can see that this often times seeks to be hit or miss! CS is much less toxic to normal cells than chemo. I imagine that some cancers may turn out to have a pathogen involved in their activity. CS is also an antifungal, though I do not think it is a potent one. It also has anti-parasitic activity.
Another potential mechanism for CS in cancer is the fact that CS is antiangiogenic and this is important because cancer cells tend to require more blood supply than normal cells so if you are directly killing the cells with ROS while simultaneously starving them by reducing their blood supply, well you can see the benefit in that!
On your last question about PD and my regimen, I assume you are no longer talking about CS, but rather what I used to clear my erythrodermic psoriasis and whether I think it might be helpful for PD and my answer to that would be possibly. A main component in what I used was EGCG and I believe there are enough studies about EGCG to suggest it may have an impact on PD. This topic has been described on this forum previously at length by others. I also used pine bark extract (PBE) and another topic that has been discussed previously on this forum is the role of inflammation and oxidative stress in many forms as they relate to PD. Both components are at an elevated state and are feeding off of each other in a vicious cycle because the elevated inflammation generates more ROS and more Ros generates more inflammation. Neutralizing this excess, in theory, should at a minimum slow the disease process. I chose a supplement that had both EGCG and PBE in it for ease of use. Unfortunately I had to use this supplement at a dose that is higher than can be safely recommended ! I took it because I was pretty desperate and my situation was declining rapidly. It worked better than I had hoped as it allowed me to get to a clear state over a period of months once I added the xylitol and a home made topical ointment. I've already discussed xylitol on this forum and it was chosen for the reasons previously stated, but mainly for its potential anti-inflammatory effect and histone deacetylase inhibition (HDACi). As in psoriasis and also in PD, although not often discussed, HDAC inhibition is quite important! The effects I mentioned above are only a small portion of what these supplements do, but they express the idea well enough to get an idea of what I was trying to do and was working toward.
With psoriasis as in PD, you are dealing with a run away inflammatory and oxidative stress response that is reeking havoc on our systems body wide
and these are the main reasons I chose the supplements I chose to attempt to quell this response. I do not consider the above a cure for my psoriasis, but a way that allows me to lead a normal life right along side the disease!
I am trying to research holistic approaches for the symptoms of parkinson's as my dad was recently diagnosed. He hasn't found much relief in the prescribed medications from his doctor so I would really love to help him out. What brought me to this thread was that a friend of mine and her husband recently started taking xanthohumol to help with his prostate cancer. I in turn thought that it may also be beneficial for Parkinson's as well and when I did the search in google, I ended up here. Are you able to provide any additional insight as to the below? When i searched for Mannitol all I could find was a form that is given through IV and it seems like what is mentioned below is taken orally. I would love any other info on any other holistic approaches you could provide!! TIA!
Mannitol 2 Tbs morning
S-methyl-l-cysteine 1-3 GMs 12 PM mixed with water or juice (dont take it with sinemet).
MTC oil 2 TBs at 1 PM (don't take it with sinemet).
Xanthohumol powder 98% one TS mixed with water at 8 pm
Mannitol is available online - I can find it on Amazon.com if you are based in the US.
Sound's like you are doing a good job researching. Not all of this stuff will be beneficial, but hopefully with trial and error you will get something that should help.
I am now taking a supplement that includes Xantho. and I also add another Nootropic in the form of a coffee. I was def a Nay-Sayer on all this MumboJumbo. But, after 1 month, I'm a believer. Evenmore, my friends who have anxieties, diabetes, are extremely benefiting from the SmartCoffee/HappyPill (Xantho). Please don't think I'm a sales pitch, but here is a link to see (and note: the smartship is the best price: $40 each and u only need 1 pill). Elevacity.com/LindaLuLifestyle
I am now taking a supplement that includes Xantho. and I also add another Nootropic in the form of a coffee. I was def a Nay-Sayer on all this MumboJumbo. But, after 1 month, I'm a believer. Evenmore, my friends who have anxieties, diabetes, are extremely benefiting from the SmartCoffee/HappyPill (Xantho). Please don't think I'm a sales pitch, but here is a link to see (and note: the smartship is the best price: $40 each and u only need 1 pill). Elevacity.com/LindaLuLifestyle
I am now taking a supplement that includes Xantho. and I also add another Nootropic in the form of a coffee. I was def a Nay-Sayer on all this MumboJumbo. But, after 1 month, I'm a believer. Evenmore, my friends who have anxieties, diabetes, are extremely benefiting from the SmartCoffee/HappyPill (Xantho). Please don't think I'm a sales pitch, but here is a link to see (and note: the smartship is the best price: $40 each and u only need 1 pill). Elevacity.com/LindaLuLifestyle
I am also beginning to wonder the worth of big pharma with parkinson's. There is so much stuff here which seems to help. But everything big pharma research doesn't seem to improve matters at all. It seems the same with type 1 diabetes.
Big-Pharma is interested in BIG MONEY, people's health is a side effect that they are willing to tolerate. Sad but true.
That is why we don't have GM1 as a treatment , sheep farms don't fit well with Venture Capitalist, they are willing to put billions for research BUT has to be THEIR WAY. Read the SAD story about GM1 in this post :
I am still not sure about how to take Swanson's Xanthohumol, that poster you mentioned bases the empty stomach on Nilotinib instructions I think.
Nilotinib maker Novartis says take it on empty stomach, because with food, it has unpredictable levels.
Xanthohumol is a Neutraceutical a flavonoid, food might improve absorption.
I take Curcumin for example with fatty meals otherwise its a waste, very little gets absorbed.
Unless Xanthohumol is studied for its pharmacodynamics we will not know for sure.
As a test I took this morning dose of 10 Swanson caps on empty stomach. NO side effects.
I am also thinking of raising the dose to 20 caps a day, 100mg total Xanthohumol, I am very sensitive to side effects and stomach issues and does not appear to have any side effect till now.
Curcumin does not get absorbed unless taken with a FATTY meal.
Mannitol is a sugar, a carb, not fat.
The best formulations of Curcumin come with Bioperine, Black Pepper, increases absorption they claim several times, pepper causes heart burn so its out for me.
Then we have the pricey curcumin with Soy Phospholipid, Brand name Meriva, from Italian company Indena under many labels.
Occasionally still partaking of a hoppy IPA and I take my curcumin with my heaviest (fat) meal. I believe we are on the right path in using these anti-oxidants
I am now taking a supplement that includes Xantho and Turmeric (best combo!). and I also add another Nootropic in the form of a coffee. I was def a Nay-Sayer on all this MumboJumbo. But, after 1 month, I'm a believer. Evenmore, my friends who have anxieties, diabetes, are extremely benefiting from the SmartCoffee/HappyPill (Xantho). Please don't think I'm a sales pitch, but here is a link to see (and note: the smartship is the best price: $40 each and u only need 1 pill). Elevacity.com/LindaLuLifestyle
I recently bought some Xanthohumol from Swanson based on what I read here. I've taken it for two nights, just one 50mg tab. I couldn't believe how fast I responded. In less than 1/2 hr I was drowsy and slept through the night last night. I usually have to get up once or twice a night. I haven't taken it in the daytime yet. I can't imagine taking 10 like I saw on some other posts.
50mg RAW HERB, from hops, standardised to 10% Xanthohumol,
that is just 5mg Xanthohumol.
I have taken 10 caps a day for 3 weeks now, gone through 3 bottles already, I have read that it does cause sleepiness, but even at that dose I get none of that !
The objective is not to relax or put you to sleep, but to inhibit or clear A-Synuclein, and I don't know what that feels like, so I have no way to evaluate it but my symptoms, have not seen anything yet, but took Nilotinib 1 month for subjects to see a difference, the trials go on.
One thing I learned when getting Hashimotos under control was that different people react to different substances and you really have to test them out. I was amazed to have this reaction to this product. I've taken other things with no reaction at all. I take a supplement that has maitake mushrooms, lemon balm, pomegranate extract, echinacea extract, licorice extract and a couple other things. Within two days of taking this it was like night and day for me on how I felt but on the other hand drinking milk (even raw or goats milk) taking grape seed oil or coffee or tea do the opposite. Some people feel better drinking coffee and it's not bad for them. I don't think there is one size fits all.
I am now taking a supplement that includes Xantho. and I also add another Nootropic in the form of a coffee. I was def a Nay-Sayer on all this MumboJumbo. But, after 1 month, I'm a believer. Evenmore, my friends who have anxieties, diabetes, are extremely benefiting from the SmartCoffee/HappyPill (Xantho). Please don't think I'm a sales pitch, but here is a link to see (and note: the smartship is the best price: $40 each and u only need 1 pill). Elevacity.com/LindaLuLifestyle
And all this supplement popping is NOT scientific, not double-blind controlled, and probably will kill the lot of us! Yes, I will go on record to say that Parkinson's doesn't kill you, all the looney advice you get online is what kills you! Oh, and get some exercise!
I have gotten into the habit of imbibing a A few swallows of hay happy IPA every evening before bedtime and I’m insured that contains enough antioxidant to do the trick it seems to help me sleep to
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