I take sinemet 25/100 about 4-5 times a day. I've been on this schedule for at least a year and it's been working great. 2 wks. ago I went on vacation to Cancun, Mexico and soon after arriving I started getting really bad wearing off symptoms-very stiff, bending forward at the hips, blank stare, etc. I thought it was due to the 4 hr. flight. But the whole time I was there, my medication wouldn't work like it has been for years. I couldn't get it right, I started taking 7-10 pills a day, and it still was hardly working. I've been home for 6 days now and I'm still having the same problems. Has anything like this happened to anyone else? Or does anyone know what is going on or what I should do, besides calling the doctor.