flavanoids for disrupting alpha-synuclein

Fascinating tidbits: not suggesting pharmacological effects but perhaps indicating slower, milder effects? Each reference is open access.

Excerpts

"The aggregation of α-synuclein is one on the key pathogenic events in Parkinson's disease." (4)

"A variety of flavonoids inhibited alpha-synuclein fibrillation, and

most of the strong inhibitory flavonoids were also found to disaggregate

preformed fibrils." (1) "Table S1 in Supplementary Materials....

lists the name, synonym, and structure of the flavonoid from each

class." (2)

"To develop disease modifying therapies for α-synucleinopathies, we

examined effects of phenolic compounds on α-synuclein (αS)

oligomerization. Phenolic compounds, especially Myricetin (Myr) and

Rosmarinic acid (RA), inhibited αS oligomerization and secondary

structure conversion. Myr and RA ameliorated αS synaptic toxicity on the

experiment of long-term potentiation. Our results suggest that Myr and

RA prevent αS aggregation process and reduce the neurotoxicity of αS

oligomers." (3)

"Piceatannol inhibited the formation of α synuclein fibrils and was able

to destabilize preformed filaments. It seems to induce the formation of

small soluble complexes protecting membranes against

α-synuclein-induced damage. Finally, piceatannol protected cells against

α-synuclein-induced toxicity." (4)

"Red wine is particularly rich in specific polyphenolic compounds that

appear to affect the biological processes of AD and PD, such as

quercetin, myricetin, catechins, tannins, anthocyanidins, resveratrol,

and ferulic acid. Indeed, there is now a consistent body of in vitro and

in vivo data on the neuroprotective effects of red wine polyphenols

(RWP) showing that they do not merely possess antioxidant properties,

but may additionally act upon, in a multi-target manner, the underlying

key mechanisms featuring in both AD and PD. Furthermore, it is important

that bioavailability issues are addressed in order for neuroprotection

to be relevant in a clinical study scenario. This review summarizes the

current knowledge about the major classes of RWP and places into

perspective their potential to be considered as nutraceuticals to target

neuropathology in AD and PD." (5)

References

1. Effects of Various Flavonoids on the α-Synuclein Fibrillation Process.

Meng X, Munishkina LA, Fink AL, Uversky VN.

Parkinsons Dis. 2010 Jan 28;2010:650794.

ncbi.nlm.nih.gov/pubmed/209...

2. Table S1

downloads.hindawi.com/journ...

3. Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity.

Takahashi R, Ono K, Takamura Y, Mizuguchi M, Ikeda T, Nishijo H, Yamada M.

J Neurochem. 2015 Sep;134(5):943-55.

ncbi.nlm.nih.gov/pubmed/260...

4. Piceatannol and Other Wine Stilbenes: A Pool of Inhibitors against α-Synuclein Aggregation and Cytotoxicity.

Temsamani H, Krisa S, Decossas-Mendoza M, Lambert O, Mérillon JM, Richard T.

Nutrients. 2016 Jun 15;8(6). pii: E367.

ncbi.nlm.nih.gov/pubmed/273...

5. Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer's and Parkinson's Disease.

Caruana M, Cauchi R, Vassallo N.

Front Nutr. 2016 Aug 12;3:31.

5 Replies

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  • One more cite, also open access:

    Effect of curcumin analogs onα-synuclein aggregation and cytotoxicity.

    Jha NN, et al.

    Sci Rep. 2016 Jun 24;6:28511. doi: 10.1038/srep28511.

    ncbi.nlm.nih.gov/pubmed/273...

  • Thank you for posting this. The trouble is I can't make sense of it. Could someone boil it down to essentials. I'd be very grateful, all I can get is that red wine is good the rest is blah!

    Oh dear, if I only had a brain!!

    Best wishes.

  • ditto

  • Consider Table S1 in cite 1 of original post. Table S1 reports that

    quercetin and myricetin (a naturally occurring molecule found in various

    foods) are "inhibitors of α-synuclein fibrillation" and thus might

    impede progression of PD progression related to alpha-synuclein.

    However, we must be prudent; findings from animal studies and from in vitro studies do not

    necessarily apply directly to humans. Goal is to identify dietary and

    non-dietary factors that might ameliorate or delay PD effects.

    1. Effects of Various Flavonoids on the α-Synuclein Fibrillation Process.

    Meng X, Munishkina LA, Fink AL, Uversky VN.

    Parkinsons Dis. 2010 Jan 28;2010:650794.

    ncbi.nlm.nih.gov/pubmed/209...

    healthunlocked.com/api/redi...

    2. Table S1

    downloads.hindawi.com/journ...

    healthunlocked.com/api/redi...

  • Thank you; based on this it might be useful to add Quercetin to one's diet. It can't do any harm and might even do some good! And red wine too.

    Best wishes