The Latest in Efforts to Develop a Vaccine against Parkinson’s

[PDWarrior1900]

I just got this email from the Michael J. Fox Foundation

"A vaccine to slow or stop Parkinson’s – which received early funding from The Michael J. Fox Foundation – is safe and induces antibodies, reports a recent paper. Researchers recently completed a randomized first-in-human study of UB-312, a vaccine they hope will prove effective against Parkinson’s. This phase of the study, completed by Vaxxinity as part of an ongoing clinical trial, examined the effectiveness and safety of the vaccine in blocking toxic build-ups of the alpha-synuclein protein – a pathological hallmark of Parkinson’s and a priority target for drug development."

michaeljfox.org/news/latest...

-------------------------------------------------------------------------

There's over 130 international clinical trials going on RIGHT NOW!

STAY STRONG!

(I just got back from a two hour bike ride!)

A 'MIRACLE CURE' is just around the corner!

[saraoutwest]

Let’s hope so

[jimcaster]

I sure hope this proves to be successful, but I am struck by this sentence:

"With these results, researchers hope this vaccine can reduce or even block alpha-synuclein build-ups and prevent neurodegeneration (the cause of motor degeneration and non-motor symptoms)."

I am skeptical about the assertion/assumption that alpha-synuclein build up is the cause of motor degeneration and non-motor symptoms. A similar assertion/assumption regarding the build up of beta amyloid appears to have led to decades of futile Alzheimer’s Disease research.

[Jana86 in reply to jimcaster]

Agree. There is really important debate about this and we should be cautious about optimism.

[LAJ12345 in reply to jimcaster]

Yes, what if people who are developing PD produce the alpha synuclein to protect their cells? And they are stripping it away. Mmm

[John_morris71 in reply to jimcaster]

They should try to find out why the alpha synuclein aggregates and forms fibrils.

[redhawk1 in reply to jimcaster]

Hi Jim . . . it is my understanding that it is conjectured that the cause of Parkinsons is initiated by the aberrant misfolded alpha synuclein proteins. Hopefully, all the money spent on this theory is because the blind have been following the blind!!

[jimcaster in reply to redhawk1]

Correct. But it has also been conjunctured that Alzheimer’s is initiated by the aberrant misfolded beta amyloid proteins. As I understand it, various Alzheimer’s drugs have been designed to remove or prevent beta amyloid accumulations, but have not affected the underlying disease. A recent post on this site suggests that the initial claim that misfolded beta amyloid proteins cause Alzheimer’s was fraudulent. It does seem to be the blind leading the blind. Ugh.

[Parky11 in reply to jimcaster]

Check out A C Immune who recently acquired the PD Vaccine portfolio from AFFRIS. Tracer capability now measures alpha-synuclien...msg. me if you can update,thanks

[Gcf51]

My feeling is the study on Alzheimer's may have been modified to support the claims, but doesn't necessary mean the claims were completely false.

[pacwest]

In the meantime keep riding your bicycle !

[redhawk1 in reply to pacwest]

Ha!! Ha!! Just got done with my spin class and despite the monoclonal antibodies I get every 28 days it’s not getting any easier!

[kaypeeoh]

PD is often lumped in with MS; Both are brain dysfunctions. Autohemotherapy (AHT) is an old treatment. It was popular until the advent of antibiotics in the 1940's. But it also treated conditions like MS. I was dx'd with MS years ago. After reading about AHT I tried it on myself. Ultimately the MS was cured. Now that I have PD I'm trying it again. AHT is a very simple treatment; With 40 years of medical experience it's easy for me to do. Vaccines produce antibodies that treat disease. AHT produces antibodies that stop MS. I wonder if AHT can treat PD. Eventually I'll talk to my neuro about this. But for now I'll continue with monthly AHT treatments.

[LindaP50]

My hubby, PWP and I signed up for the study. Sent this link to a few PD Support groups so others could sign up.

I thought this was good news, is it not? PPMI: the Study that Could Change Everything.

michaeljfox.org/ppmi