Hi there, At the moment I can`t see the wood for the trees and wonder if anyone may be able to help. I`ve been taking both the tramadol and pregabalin for nerve pain for two years, since then I`ve been diagnosed with osteoarthritis in my sacroiliac joint and interstitial cystitis, so I`m not sure if the nerve pain was the correct diagnosis. However at my last appointment at the pain clinic the nurse prescribed slow release tramadol, 100mg to be taken at night and morning, with the option to add my 50mg tablets during the day if I need to, for the OA.. These worked very well and I rarely needed the extra- however I`ve started sweating really badly, to the effect that its upsetting my life, so I stopped taking them and resorted back to taking the 50mg if and when I need them, which is only about once a day now. Do you think this sweating is withdrawal or is it maybe the double dose of pregabalin and tramadol that I`ve been taking? As my pain seems (fingers crossed) a bit better I`d like to stop both drugs and as I`m only on 100mg pregabalin once a day now would it be safe just to stop them? Because of the interstitial cystitis I also take 100mg trimethoprim once at night. I did try to ask my doctor these questions but I didn`t get very far with him- I think he was having a bad day.