Carbo/Caelyx Cocktail

[Fizzgirl]

Hi I've got Stage3c OC have had debunking, chemo recurrence after 4 years and now one year after its reappeared. Consultant wants me on carbonation and calyx whereas before was carbonation taxon. Just wondered if anyone had been on this regime and do you have any tips please.Thankyou

[doodoolatrice]

I'll be interested to know what others think as I've been offered this combo also, Kerry x

[Caleda4]

Hi, I had six cycles of carbo/ caelyx from April to August 2022. I found it much easier than carbo/taxol. At present I am on watch and wait,due a CT scan end of this month again. It is recommended that you use an emollient on palms of hands and soles of feet. Mouth ulcers are another thing, but I only had a couple, and used only over the counter products,which worked for me.I hope you get on alright on this regime. I was prescribed by Oncologist filgastrim injections, which were for five days after each treatment,as white blood cells seem to get affected by this chemo. Take care.z

[Fizzgirl in reply to Caleda4]

Thank you very much for the reply xxx you take care too- I will be on watch and wait after as Parps stopped working after 10 months xxx

[Flute_7]

Good morning Fizzgirl, Carboplatin and Caelyx didn’t work for me, by the end of the regime my CA125 was creeping up. 4 months later I was re diagnosed and put forward for a trial the Royal Marsden.

For me the Neutrophils were affected and like Caleda4 I was on Filgastim injections. I was given 7 for the week but it wasn’t enough so chemo was continuously being pushed out by a week and I was given a further 3 injections so 10 in total.

Whilst it didn’t work for me there are others on this forum who found it did work for them, we are all unique and despite having stage 3 it may work much better for you than me. I may be wrong, but my understanding is that there is a protocol that hospitals follow and Carboplatin / Caelyx usually follows carboplatin /Taxol. Very best of luck xxx

[Fizzgirl in reply to Flute_7]

Thank you for the information it's much appreciated xx take care xx

[NewtonEmma1900]

The thing that I have learned from this forum is that one drug does not fit all! I was diagnosed 3c peritoneal/ovarian Oct 21. I had 4x carbo/taxol/ avastin followed by debulking and then 2 more. My CA 125 came down to 128 but after surgery rose again to almost just over 400. I had 2 rounds of avastin alone but CA 125 continued to rise. In July 22 I had a PET scan which showed further spread. My oncologist was not hopeful but he put me on carbo/caelyx. By January my CA 125 was 7. I had far fewer side effects on caelyx than taxol, no neuropathy or hair loss but I did have a few mouth ulcers and dry skin on my feet. Like others I did have the filagastrim injections but I had them for seven days after chemo.

(I am now on the maintenance drug Niraparib but it’s playing havoc with my platelets, hopefully the dose will be sorted out soon - it’s all a balancing act).

Very best wishes on your journey. Katy

[Fizzgirl in reply to NewtonEmma1900]

Thank you for your reply and good luck in the future xx

[Realistic]

Good luck with your new treatment, and no truer words than one of the girls were all different so we all take treatments differently. Hope it works for you. Love & hugs SheilaFxxx

[Twinning]

I am currently on Caelyx/Carboplatin; 2 infusions in. I am tolerating it well; just a little nausea a few days after. My second infusion was delayed a week due to low neutrophils. That didn’t do the trick so was given a shot of Neulasta after the infusion. Hoping that helps and there are no further delays.

I lather up my feet with thick lotion every day and wear cotton gloves on my well lotioned hands at night. So far so good.

I was offered taxol/Carbo but I have neuropathy from my first two occurrences so I declined so as not to worsen my hands and feet. Hoping this regime works for me. To be honest, since there are 4 weeks between infusions I sometimes forget I’m even on chemo.

Good luck to you.

[Fizzgirl in reply to Twinning]

Thank you for your reply its comforting to know - good luck to you xxx

[SKpaints1]

i was on this regime for 6 months .. i to was stage 3 c disgnosed in 2019 full debulking, bowel resection and carbo/taxol chemo first recurrence in 2022.. i had 6 months of carbo/caelyx.. fatigue was biggest issue together with very sore feet and hands.. it’s doable but you need to rest .. Im now on a parp inhibitor called rubraca, im looking to have the dose reduced as struggling with side effects … really hope you manage your treatment well . Take care

[Fizzgirl in reply to SKpaints1]

Hi I've been on Rubraca for 10 months but struggled with low Hb so had x2 dose reductions. Unfortunately CA125 is rising so they have taken me off it and have to go for chemo then wait and see. I wish you all the luck in the world and hope you respond well and can keep using it for years xxx

[delia2]

I found carbo caelyx quite tolerable. As others aid you need to moisturize feet and hands a lot and do a gentle mouthwash for mouth sores. I was tired and slightly nauseous for about five or six days each cycle and got low platelets but otherwise okay. Good luck!

[Fizzgirl in reply to delia2]

Thankyou xx