Hi Everybody. My wife has been taking Letrozole now for a while, and whilst it seems to be doing some good on the face of it, the side effects are quite severe. Unbelievable tiredness (she was never this tired even whilst having Chemo), joint aches and general lethargy. It is a marked change in her. I don't specifically mean to make comparisons with the Chemo, but it felt like we know where we stood with that (perhaps you get used to the 'cycle effect between treatments). With Letrozole it just seems different. Sustained. Constant. I feel like this is changing her from the person she was. Withdrawn and distant. Has anybody else experienced this or any of the traits above?