Zoledronic acid plus teriparatide

[tcpace]

Hi everyone, newbie here. My wife is about to go onto treatment for fairly severe osteoporosis after a fall involving fractures to 3 lumbar vertebrae. According to a letter from her consultant to her GP, the consultant seemingly wants her to go onto zoledronic acid plus teriparatide. We're due to discuss/start the treatment in a couple of weeks time. Just wondering if anyone else has experience of both zoledronic and teriparatide treatment at the same time? I find it puzzling because wouldn't the zoledronic negate the superior bone-strength building attribute of teriparatide? As I said I'm a newbie to this so I may be totally wrong.

[bellybuddie]

it’s very common to do teriparatide for 2 years then followed by zolendronic acid infusion. but together? haven’t heard of it

mass general has clinical trials doing forteo with Prolia together with very good results

[uncountable3]

There have been studies showing promising results by combined anabolic and bisphosphonate therapy. Here is one: ncbi.nlm.nih.gov/pmc/articl...

Also, endodoc, who posts on Inspire occasionally, is a proponent of alternating anabolics and bisphosphonates. Typically three months of anabolic like Forteo, switch to bisphosphonate for three months, then back on the anabolic.

[FrogLeg]

A brief Google turns up at least this one article about combination therapy in women:

nature.com/articles/nrendo....

As a male, I take teriparatide daily. I would want more info from the specialist on their thinking. I would also compare against standard endocrine clinical guidelines. I suspect this is a novel use clinically.