has anyone used leflunomide?: i have just been recently... - NRAS

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has anyone used leflunomide?


i have just been recently diaginosed and see my rheummy nurse on 14th january which is when i gonna start using this drug. its just not one of the ones that people on this site seemed to have used or mentioned when i told my gp thats what i was starting she said thats one of the new ones. would appreciate any comments take care all michelle x

8 Replies

Hi there.

Just a message to say hello and I take Leflonmide. I have taken it for 5 weeks. I have had very few side effects from it apart for some loose bowels for a few days and a bit of tummy upset.

I always take it after breakfast. I take it with Methotrexate injections.

Hove this is helpful to you. My symptom have slightly improved on the dual therapy but it is early days yet. I am hoping for more improvement over the next few months. My inflammatory markers are reducing so that is a good sign.

Best wishes



Hi, I have been taking these tablets for 18 months, first with MTX for six months and with Embrel injections for a year. Like Carol has said I have noticed the same side effect as her but I had put mine down to IBS, as I suffer from that as well. Recently I have had to reduce the tablets to every other day due to low blood count. Hopefully going back to full dosage after my next blood test.

Mine combination suits me, I feel better within myself than I have done for many years.

Take care.

Im on 20mg of Leflunomide after still badly flaring on 10mg. Had few side effects ie tummy ache but no bad symptoms like i had on mtx.

Hope you too will be fine on them.


I was only on it for a short while, as i could not tolerate the side effects. That was mainly food related. I could not stand to eat. I was so nauseated and stomach upset, i hardly ate. I did not smell, or have the sense of taste of food, yet could not stand to eat. It was a strange experience.

I hope you do not experience these things at all. It seems to have worked for many people, so maybe you will be one of those.

Good luck to you.

thanks for that guys :) michelle x

Hi Michelle, I've been on it for about 20 years and I haven't noticed any side effects from it. I was prescribed Mtx at the same time so I don't know which one is giving me a metal taste when I take it-but I think it is the Mtx.

Good luck,


Hi Chemar

It sounds like you've already had lots of useful info from the folks on here but I thought I would also send you a link to our article on leflunomide: nras.org.uk/about_rheumatoi...

We also have a good 'Newly Diagnosed' booklet which is availabe to download from the website which you might find helpful at this time: nras.org.uk/help_for_you/pu...

I hope you get on well with the leflunomide in the new year.

Kind regards

Sarah Kate


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