I have had to come off Mxt due to rising liver enzymes, but it looks like that might be a red herring. My liver enzymes were only slightly raised until 7 weeks after stopping the Mxt when they went through the roof! The docs were insisting that the drug was responsible, but they are now querying AIH - even though my antibodies are neg. Have had a good response to steroids, and liver relapsed when steroids stopped, so looking more like AIH than drug toxicity. Still no firm diagnosis yet though. It's very frustrating that I was very well controlled on MXT for 12 years, and now I have very active RA! Thank goodness for Depo-Medrone - keeping me going until docs decide what other drug to give me!