Evening or morning methotrexate

[Jacojudy303]

Happy New Year people!

I was just wondering if anyone has experience changing the time they take methotrexate. I'm considering switching from morning to evening as it makes me feel a little nauseous during the day, and I think I might not notice this so much while sleeping. Any thoughts? I've been taking 20mg for seronegative inflammatory arthritis for about a year and am currently in remission.

[welsh12]

I take it in the evening with a meal feel pretty ok the following day occasionally not so good.

[Jacojudy303 in reply to welsh12]

thanks welsh12 I'm going to give it a try.

[Runrig01]

i take it in the evening, so I sleep through side effects. I did once have to hold off, as hubby was waiting on a covid test, it came back negative, so I took it that morning. Ended up spending the day in bed utterly fatigued. Yet I don’t get fatigue or nausea taking it at night.

[Jacojudy303 in reply to Runrig01]

That's what I thought Runrig01 , thanks

[Ruth12345]

I now take mine just before I go to bed. It's really helped with the nausea. I have the odd time when I'm not so good, but so much better than I was when I took it in the morning. It's been well over 7 years since I changed.

I wish you all the best.

[Jacojudy303 in reply to Ruth12345]

Thanks Ruth12345 I don't know why I didn't think of it before!

[Ali_H]

I split mine and take half with breakfast and half with tea, this helps me and is accepted by rheumatologist as good practice to keep med viable for me. I also take Baricitinib every morning.

All the best

Ali

[Madmusiclover]

evening every time. I’m only on a low dose though.

[Boxerlady]

I inject early evening. I find that the side effects (usually tiredness rather than nausea) kick in 24 hours later so I feel tired the following evening which is better than in the morning, I suppose 😁 I started on tablets and took them after tea as I took my Hydroxychloroquin after breakfast.

[Hollyhock123]

Hi, I have pre-filled injection pens and do that before bed as I find I feel really tired. When on tablets, I took with my meal in the evening to lessen any nausea.

[ABwn]

I take it late afternoon, when I'm not taking any other medication. The following day, similar to others, it has a slight detrimental affect. Good luck.

[Tiverland]

I changed due to same reason . Take mine half way through an evening meal. Then a glass of tonic water after my meal and the nausea goes away almost immediately.

[CagneysMum]

It use to make me feel nauseous so I started injecting after my evening meal which is much better. Sometimes it stings when I inject but hardly ever feel nauseous now. Keep hydrated too. Good luck 👍

[ruth_p]

I switched from morning to evening to try and stop the side effects. I found it much better that way. I then miss the folic acid the next morning. X

[MadisonCounty]

My rheumatologist recommended half after breakfast and half in the evening. It seems to work well for me.

[DoraBracken]

I also was recommended to take methotrexate last thing, though I don't seem to get nausea. I wouldn't worry about changing the time you take it. I occasionally move my medication day if I need to.

[Purple4710]

I take my Methotrexate before I go to bed but don't get any nausea

[MerielPB]

I take it last thing when I go to bed. The theory being that I will sleep through any side effects. It seems to work.

[Jacojudy303]

Thanks for the advice everyone. Tried taking it last night. Much better on the tummy. I was a little slower than usual when I ran this morning but I reckon that’s cause it’s freezing here in London 🥶

[Seatgeorge]

Allways take mine on saturday morning with my porridge never had a problem

[Koroush]

I have been on methotrexate 20mg / 3 years always took it before going to bed all fine

[Porridge-]

I switched to evening. Definitely worked better for me. Though still sometimes hits me the next morning.

[cyberbarn]

I was doing the injections in mid morning, and the very painful gut reaction started just as I was going to bed and kept me up all night. But it would have been just as bad to have the pain during the day, or waking up with it, or when ever, so I stopped. But for 5 months I had no problem doing the injection mid morning.

[Froggie70]

Hi I split mine as I had the most awful nausea so Rheumatology nurse suggested trying this. I take half at lunchtime and half with dinner and it seems to have helped.

[PMRGCA19]

I changed my metoject pen to last thing at night to avoid nausea - it worked!

[Jig-saw]

Hi, sorry to hear you’re having problems, because of sickness I was informed by the nurse team that I could split my dose to half in the morning and half in the evening and that I could increase my folic acid to every day except methotrexate day which has resolved my problems

[Popinjay]

I have always taken mine just before bed and found this the best time, some times i am still off colour the next day but the worst is usually over by the next day.

[Happy5]

I'm on MTX injections, for me I take anti sickness meds (prescribed) half hour before doing the injection. Do my injection before bedtime to sleep through worse symptoms.

We're all different so find what works for you.