3 in 1

[cross2]

My doctor c

Is putting me on 25mg methotrexate once a week although with 600mg of salfrazine twice a day and 200mg hydroxycolorquinne per day. Anyone else tried this combination?

[helixhelix]

I was on that mix for about 8 years, and it got me into remission for 7 or them! This triple therapy went out of favour for a while, but research has shown it’s just as good as biologics.

Hope you do as well on it as I did.

[cross2 in reply to helixhelix]

Thank you that is what mr consultant is hoping as am I. I was hoping he would take me of f the metho as I get a huge hangover from it so was shocked when he tripled the dose. Here’s hoping.

[Boxerlady]

I'm on that combination but on slightly different doses. It's been good for me but recently I've been having a few niggles so I'm hoping that my consultant will have some thoughts about tweaking the doses when I see her on 10th August. I'm currently on 20mg Methotrexate (injection) weekly, 2 x 200mg Hydroxychloroquin daily and 3 x 500mg Sulphasalzine twice a day..

I've been on that dose of Hydroxychloroquin from when I was first diagnosed in 2019 (they've tried to drop it a couple of times but had problems quickly) and the Methotrexate and Sulphasalzine doses have been increased over time. I did try Methotrexate at 25mg for a while before adding Sulphasalzine but it didn't help whereas the Sulphasalzine definitely did.

[cross2 in reply to Boxerlady]

Thank you that was useful inwards and upwards

[Scottishlad]

It worked well for me for a few years but eventually became less effective and I was put on a biologic.

[Ruth12345]

I'm basically the same as Boxerlady but been on the 3 meds for about 6 years. Now not working quite so well, but still much better with than without. I take mthx orally.All the best 🌻

[Hopeful1]

Yes. Worked well for me for years. Good luck.

[PrexistngCndition]

Sort of.

My Rheumatologist intended similar triple DMARD mix when I was diagnosed in 2016. Drugs were individually phased in over a few months.

I reacted badly to sulphasalazine (rash and nausea) and had to stop it after a couple of months at most.

400mg hydroxychloroquine to present.

Initially on oral methotrexate but gave me nausea and diarrhoea. Changed to subcutaneous, which is ok. Dose ramped upwards initially until 25mg, but after a few years has now gradually reduced from 25mg to 20mg and currently 10mg in a precautionary response to some raised liver enzyme results.

Symptoms now good 95% of the time, but just now and then reminders with periods of “stinging” across palms and a few small foot and finger joints become sensitive. Nothing to the disabling pain, fatigue, sandpit eyes and general misery I had after the onset.