Check out question and answer session where someone asked about what we should expect in re immune response to vaccine. She states that we should probably get 2nd sooner and even possibly 3rd dose. She suggested we should all be speaking to our specialists and getting our response monitored
Interesting!?
I dont know who did the interview but there is an ongoing study into if immuno supressed such as those on cancer therapy and immunosupressant therapies get less protection than healthy people.
Certainly it is possible and not that surprising but according to the vaccine studies the main thing is vaccines will stop everyone whatever condition becoming hospitalised or dying of covid which I find reassuring. I think it's not so worrying for me catching covid when I realise I wont get extremely I'll.
The government are already saying they have been looking into it so asked us all to shield until Aptil so I personally would suspect their reply by then such as potentially the vaccine response is not largely affected or it is only slightly affected or we will bring forward second doses.
They have already said to that the elderly / potentially vulnerable people may require another jab in the autumn which is tweaked for the south African and brazilian variants and it inevitablhbwill be a few seasons of vsccines etc but I think it will sort out.
I think theyve been onto this for months , it's not a new concept in vaccines which is why they were delighted when the efficacy for over 65s was excellent.
So I'll continue to shield, etc like we were advised until more evidence is brought forward by the chief scientific officer and chief medical officer.
Have you got a link to the programme ? Love to hear it.
Will listen, thank you. Another consultant of mine (not my rheumy) said the same to me this morning on a phone consultation. He is writing to my GP. Not sure if he will make a difference. Elderly immunodeficiency were the group that is looking to possibly receive a third dose in September, but I didn’t read anything to say who else will be included for a possible third dose.
I am having my antibodies monitored more closely at the moment to see when I repopulate B cells for the purpose of my RA med but guess the ones I had last week may show if my igG has been affected by a rise in antibodies. It’s not for antibody testing to vaccine response my nurse is doing it for though. It’s to to try pinpoint when I repopulate B cells more accurately.
It's on bbc now on corona virus catch up
Just listened to it on bbciplayer. Had some reassuring advice for those thinking a milder vaccine response for some means not enough immune response.
Reassuring as they think the immune response still to be good?.I know the study isn't out till December
Yes that too but as you say the data from studies of the immunosuppressed will show just how we have responded. Thank you sallygrain for telling us about it.
25 million had the jab so far, being rolled out to over 50 ( but the guardian has just said there will be a shortage?) Good protection in over 70ns , risk of hospital admission reduced by 80 % , two dose of fizer first 84% reduction of dying .
Health workers now less if vaccinated likely to spread it transmit virus to patients and reduces spread to their households
75% of older groups have antibodies in the blood .
JVT said , we want to catch all phase 1 before moving onto phase 2 . Vaccines are safe , eu blood clots stories rubbish . No indication that vaccinations cause blood clots . Still working on evidence of course ongoing that no excess or increased risk, final
conclusion . Benefits are better than the risks.
Shielding will end on 31st march. You can go back to work.
Keep following road map . Measures for all people will be lifted at once , an ability to show you have had the vaccine for travelling will be decided
NHS letter says there is a significant reduction in supply as Brussels want uk vaccines. He said vaccine supply is lumpy and it is a standard letter , so firstly doing all groups 1 to 9 then plan to continue as planned.
Supply from EU our government funded the supply chain and the AZ vaccine and we legally signed a contract for 100 million , he feels supply of vaccines are contracted to uk and will be delivered on , she , the president of eu, cant say otherwise I can assure people we have enough supply and over 50s by april and all adults having jabs by end of july.
26 april possibly maybe travel over borders if all stays the same ..
Nothing more about immunity ...
Theres some headlines!
Just to add do take a look at what radio 4 has on its schedule in relation to the Cov 19 The doc series How to vaccinate the world has been brilliant and also More or less the series on statistics which has dealt with Cov very well. I wonder to what extent we have any right to ask for our response to the vaccine to be checked out. Just have to wait and see I guess
I'll have a listen sounds very interesting . If you like this sort of stuff have you watched John Campbell on you tube?? thanks Sally x
Hi Sally, I downloaded the BBC R4 App so I can listen to the other episodes too, thankyou. I have antibody blood tests for Rituximab which include IgG, so I’m not sure if my latest ones from last week (awaiting my results) may show an increase due to the vaccine antibodies or if it’s my B cells repopulating. I’m due to speak to my biologics nurse very soon. (Before anyone tells me, I do know how IgG, IgM and IgA are affected by Rituximab and what those 3 antibodies do. 😊 I’m just not sure exactly what the test is for Covid/vaccine antibodies is, although a non rheumy consultant recently told me it is IgG they test for.) x
Hi - sorry but please could you explain something more about IgG for me a little more if possible? No worries if not.
If our IgG (and IgA) are already elevated as part of our disease and only immunesuppression brings IgG down to just within range - does this mean the vaccine should send it back up again or bring it down to within range do you know?
I have Hypergammaglobulemia relating to Sjögren’s (I also have Scleroderma and mild RA). Ta 🙂
As well as having total immunoglobulin tests, you can test if you have IgG against certain diseases such as; Covid. If positive, this usually means you’ve had the virus or you’ve been vaccinated. However, there is another part of the immune system called T-cells which may also protect you even if you don’t make the antibodies. Just to add, if you have an immune system disorder you may not make antibodies but could theoretically, still have some protection from Covid.
Thanks for explaining. I had total immunoglobulin tests in December as part of my immunology panel. But not seen results and my rheumatologist just said all same as usual ie high antibody specific to scleroderma and raised IgG and IgA relating most to Sjögren’s but also to my mild RA.
I ask here because I would love to have been part of the immune compromised trial Allanah mentions but no idea how to put myself forward or whether I’d be of interest or eligible. It’s frustrating when we have very unusual immunology as I do but no one seems interested in researching how well the vaccine works on us as individuals.
That said I always complete the Share forms saying that my university teaching hospital can use my blood and imaging for their research purposes - so hopefully they do.
labtestsonline.org/tests/im...
The different Ig’s are well explained in the above link if anyone wants to read re the main ones many RA patients get tested for due to their immunosuppressive meds.
Hello and sorry for my late reply but I’ve not been online so much this week.
I too thought the vaccine should send the Ig up. Not entirely sure though for myself/Rtx patients and I think that all depends on when you last had your Rtx infusion(s) and vaccine. (I left 22 weeks between last Rtx and Covid vaccine.) Not sure either re which other biologics deplete the B cells enough to make a difference? This is the same question you asked me that I want to try find out re an Ig increase after the vaccine, from my biologics rheumy. If I get to speak to her next week I’ll let you know as I’m wanting my latest Ig blood results from 10 March, which take a couple of weeks to return.
I mentioned to my private respiratory consultant yesterday about my Ig results (yes I should be asking my rheumy but I can’t get to speak to her since January 2020!) when we were having a routine respiratory phone consultation and he said although my IgG is right where it should be in the December results I may see an increase in IgG in my most recent bloods done last week as they are a month after the vaccine (and 7 months after the last Rituximab in September. Rtx is a B cell depletor/infusion.) The respiratory consultant told me IgG is the main test done for Covid/antibodies/vaccine when I asked that, but he doesn’t know what results/numbers they rise to in those Covid/vaccine antibodies tests. Just explained in more detail to me about IgG being the antibody in most abundance in the body and how it fought infections/viruses, etc. Also he confirmed what we know about mature plasma cells storing antibodies longer term for an immune response, so if your B cells are not all in tact in your blood and tissue then those plasma cells do the immune response to the vaccine. I had read that elsewhere on reputable pages.
I do know a normal range of IgG g/L is 6-16 and mine is usually 6.1-6.5 so not great but not under, and my other two main ones are just slightly under for IgM and right where it should be in the middle of the normal range for IgA. The consultant told me I was not hypergammaglobulemia and I know that is not the case. My Ig results stay constant and don’t fluctuate much at all, but I’m going to be having more regular Ig tests to see when they repopulate. That’s for RA/Rtx and nothing to do with the vaccine, but I believe there is another blood test for antibodies for Covid/vaccine and not sure which that is. Just know of the IgG and what is normal and usual for me on Rtx. So if I hear anything from my latest routine Ig results I’ll let you know! Hope you are well and steady at the mo.
I think being able to speak to our NHS doctors about any reaction to the C.V19 vaccination is a pipe dream for most of us.It took me days via 119,111,& my GP to get nowhere.I ended up seeing a consultant privately & have been told no way can I have the booster injection...& tests are still on going.
I find it very surprising that all these so-called experts both on radio, TV and in the newspapers are telling us to consult our NHS doctors ...I don’t know anybody who has a GP seeing patients face-to-face ...unless they have an ongoing condition that the GP knows about and will make an exception for.
as if thats going to happen!!!!
Feeling good - inside and out!
My fridge gave up with a months supply of Enbrel inside!
Bleeding inside the eyelid
4 Christmas: open studio
