I’ve been on mtx for 14 months now, and been taking 25mg subcut since last July. Having had a (mostly) relatively easy time of it at 15, 20, and 25mg orally, injecting initially made me feel absolutely dire for 5 out of 6 days. Then I’d have one day of feeling mostly human, only for dose day to roll round again. This gradually settled over time, but for the last month, I’ve been suffering horrendous nausea for about 48 hours post dose that no amount of water or injecting in the evening seems to solve. I’m not being sick, but it’s the intensity of nausea where I very easily could be without having to try. Eating doesn’t help (and the thought of food turns my stomach even more much of the time) and I’m at a loss as to why it’s suddenly started happening now when I’ve been on it for so long. I had a lef increase before Christmas, with 2 lots of monitoring bloods over Jan and the start of Feb, and aside from white cells being at the low end of normal, everything else was fine, including my LFTs. I’m taking 5mg folic acid 6 days a week and have been for almost a year. I wouldn’t mind quite so much if I thought it was doing the job, but aside from making my hair disappear it’s done nothing, I’ve only ever had any improvement in my symptoms with the introduction and subsequent dose increase of the leflunomide. At this point, I’m still not under control, and to some extent I’ve given up for the time being - I’ve got a lot of stuff on my plate rn with my daughter, so just don’t really have the energy to fight, and rheum are telling me that I’m not even eligible for consideration for biologics in any event. I have a call scheduled for Wednesday morning with a nurse specialist (changed from a consultant), although I’m hardly happy with them either after a complete cock up over pred and an ultrasound back in November, but will obviously bring it up during the call.
In the meantime, anyone got any thoughts or words of wisdom on this nausea business? Also any suggestions for foods that might be tolerable? I’m doing the whole bland, no spice, no seasoning, no flavour, but even dry bread tends to make me feel like vomiting. I have a lot of chronic health issues that give me symptoms on a daily basis, so I’m used to just gritting my teeth and getting on with my body being completely rubbish for the lols, but this is to the point where I’m dreading taking it and really struggling to make myself do each dose. I can’t have ginger as it triggers my arrhythmia, and peppermint is also a no go.