Recently a few RA patients messaged me to complain that they have gastric problem and felt very bad after taking methotrexate and would like to have some advice on how to minimize these problems.
I met a very good pharmacist in the early day and she told me not to allow methotrexate to come into contact with my skin to avoid any irritation. I used to vomit badly with methotrexate and felt very ill with it. I started to change the way I took methotrexate hoping to reduce all these problems. To minimize the contact of methotrexate with the lining of my stomach wall, I decided to eat half way, then took methotrexate and follow by the balance of the food.
I would like to say that it really helped in my case.