NRAS
21,419 members25,129 posts

Benepali injection

I’ve now been using Benepali for 11 weeks. It’s been amazing.

My issue is with the pain when I inject. For over a year I’ve injected MTX with no issue. However the pain with Benepali is awful! I rotate for leg to stomach and find now I am bruising after each jab. I really have to work up the nerve to do it! I have a high pain threshold but do struggle with this. Does anyone else find it painful??

31 Replies
oldestnewest

Hi I'm on Benepali as well , I'm just wondering if you take it out off fridge a couple off hours before you inject, I find it doesn't sting so much xxx

4 likes
Reply

I have been on benepali for about 5 months and have no problems with the injection. It's a prefilled pen not an auto injector.

I find Methrotrexate can sting for a little while.

I was advised to take out of fridge for an hour before I give it.

2 likes
Reply

I take Benlysta injections. I take out the fridge an hour before injection. No issues.

1 like
Reply

Hi Hevj,

With Benepali you can even take it out of the fridge the night before to make sure it's at room temperature. I do this and occasionally get a bit of stinging but that's all and the benefits far outweigh a few seconds of discomfort for me.

Hope this helps.

Love, Legs x

5 likes
Reply

Thanks folks

I take it out of the fridge about 45 mins before I use it. The nurse said not to leave it out any longer than 2 hours. I may try it at 2 hours. Fingers crossed 👍

Reply

I've tried all sorts of things but find my Benepali injections sting really badly no matter what I do, particularly when I inject into my thigh. Have been injecting into my stomach the last few times (after freezing the area with an ice pack for a couple of minutes). I leave my injection out for 1.5 - 2 hours before I inject. I shut my eyes, grit my teeth and count to 15 whilst pushing down the pen. Usually by the time I've reached 10 the stinging has stopped.

3 likes
Reply

Oh that sounds so like me! Hate injecting into the thigh- it hurts the most. Do you bruise?

1 like
Reply

Have bruised a couple of times, but don't bruise most of the time.

1 like
Reply

and me my thighs hurt so much my husband has to do then for me. my rhuemy said you can leave it out overnight. this helps a little. I am actually pain free now so not complaining really. but jeez does it hurt.

2 likes
Reply

I was exactly the same and went back to my specialist nurse and she advised me to only do it in my stomach, have it out fridge for a decent time and use ice pack before hand. She also showed me a good position on my stomach that was slightly lower than where I had tried before. Most times now I only get very slight stinging but there are definitely variables 😬 Sometimes I think if I use different “ice”... so I have a prefilled fabric covered icepack that doesn’t work so well. Ice cubes in a ziplock bag are best for me. Another variable is sometimes I know I am extra tense about it and those times I definitely feel more pain and I’m most likely to bruise then too. 95% of the time though I am pretty much pain and bruise free.

Like the others though, my overall pain relief on Benepali is massive so it is totally worth it. My nurse also said though that as a last resort if I couldn’t face using the injector pens then I could try pre-filled syringes as they might be less painful. Thankfully I’ve never had to do this. Good luck! 🍀

1 like
Reply

Hi I was wondering what benepali does? Is it mainly for pain, inflammation—only used with MTX? Thx—

Reply

It terms of the positive effects it can reduce inflammation and pain (I think it works by altering our overactive immune systems) . For me, having inflammation and pain under control also has made a lot of my fatigue more manageable and predictable. I no longer take MTX. It took me a long process of going through other drug combinations before finally getting to the point where biologics were considered on the NHS but it has been worth it in the end.

2 likes
Reply

Hi HevJ, Just like all the other posters i make sure it is at room temperature before i inject and this seems to make it so much easier and agree the benefit from Benepali far outweighs the negatives for me 30 seconds of discomfort compared to a few days of flare ups its a no brainer for me.

Good luck

2 likes
Reply

Yes it stings but more in thigh tummy not to bad but like you say it's worth it !!!!!!

1 like
Reply

Good morning yes I have the see problem I hang done in leg yet, not brave enough I've been on for 14 months, and I dread doing it, I have tried stretching skin just before stabbing myself, trying to avoid any wee fatty lumps as I have lost a lot of weight.

1 like
Reply

Hello I’m the same. My MTX injection is fine but the Benapali hurts and like you I have to build myself up to inject. I use only my thigh as inject MTX into abdomen. I don’t have an answer unfortunately. Just hang on in there or ask to change drug

1 like
Reply

Hi been on Benepali for 15 months.

I found it more painful in thigh. Rheumy Nurse suggested only injecting stomach as there was “a bit more fat there” 👍

Some injections are pain free whilst others sting.

But as others have said the benefits outweigh the sting.

Have it out fridge for at least an hour. Lie flat, count to ten, then inject. Sometimes it’s hard not to lift pen up when sting starts but grit teeth and plod on.

4 likes
Reply

Hi I have been on Benepali for 2 years and used to inject into my leg but found like you it was very painful have been doing in my stomach for about 6 months now and it is a lot less painful like everyone has been saying take it out of the fridge for at least half an hour before as it is the coldness of the medication that makes it worse. Try and inject into a fattier part of your stomach this all helps. I always find the injection gets easier in the summer when the weather warms up so you have that to look forward to.

2 likes
Reply

I have found that with Enbrel it hurts less if I inject into a fattier part of my leg. The higher on the thigh the less it hurts for me. Also take it out of the fridge for at least an hour before injecting. I watched the YouTube video that Enbrel put out and follow their instructions.

1 like
Reply

I’ve always been advised to inject into a different part of my stomach as it’s fattier and easier to do. The leg has muscle so it’s harder to inject , so I’m told, but have never tried. Get the usual raised redness but that’s about it.

Stephen

1 like
Reply

Hi,

I take the benepali out of the fridge for about 2 hours. I then put it under my arm pit for about half an hour to bring it to body temp. Put a bit of ice on where I’m going to inject for about 30 secs then inject. I do it in my thigh, works for me but we,re all different. Good luck.

1 like
Reply

If you put an ice cube on the area that you are going to inject, and hold it there for about 30 seconds, you should not bruise and it won't hurt much either. Best luck

2 likes
Reply

Hi, like you I’m on Benepali injections, I’ve been on them for over a year. They have made such a difference to my RA. I have on occasion had a large bruise, but usually I can’t tell where I’ve injected. The worst thing for me is injecting in my legs, I do rotation of 4, legs & stomach either side , when I inject in my legs it is VERY painful, it is human nature if something hurts a lot you pull away from the pain. I have done that once wasting half the injection!! Now I grit my teeth & even though it hurts like hell I keep the pressure on for the correct amount of time!!

Hope you can carry on like me & with gritted teeth think of the benefits!!

3 likes
Reply

What are the benefits of benapali? Do you take it only with MTX? Thanks for any info.

Reply

For me it’s been amazing. I had been on MTX for 4 years and doing ok. Jan 17 I started having flare ups - really severe in my shoulder and neck.

I am now on my 12th week on Benepali (as well as MTX injection) and I feel like the person I was before going down with RA. It has been a life changer. Over Christmas and the beginning of Jan I was totally crippled with RA after an op - I am a different person today!

1 like
Reply

I have been on benepali now for 5 months and I can honestly say it's the best thing I've ever had, I to feel like the person I was before I had RA i was on Methotrexate before and I thought that was alright, but this benepali has changed my life

1 like
Reply

Yes def our of fridge for a good amount of time and tummy better than leg

1 like
Reply

Hi - I have my injection day tomorrow and yes it does sting somewhat. I rotate mine in my tummy area. Do you take any other meds with yours ? I am unable to tolerate the mtx ....

1 like
Reply

Snap - my injection day is Wed too!

I also take 20mg of MTX via injection too. I can’t tolerate ate it in pill form. My rheumy nurse said once I am in remission the plan is to reduce the MTX and eventually come off it - which I can’t wait to!

Reply

Thx—what is the benepali for? I don’t know the medicine? Is it only used with MTX? You might ask about a smaller needle? See what they say.....

Reply

Benepali is a new bio similar drug replacing Enbrel. The drug is actually Etanercept.

NHS using it as it is lower cost than Enbrel but with similar results.

Reply

You may also like...