I was diagnosed last summer with Reactive Arthritis and recently went from 20mg down to 15mg orally (been on MTX for a year) as my blood checks were all good (so on paper mtx was working for me), but I felt recently that it was doing other things in me; unexplained anxiety, tearfulness, horrendous fatigue, even depression if that's possible etc, so when I was starting to have small flare ups too. I felt like something needed to change as it felt as if I was on 'too much' MTX and my body is trying to sort itself out. Does that make any sense?
The upshot is, I last took MTX on Thursday 28th Sept (1.5 weeks ago) - on no other drugs at all. I feel ok so far - just the same but clear-headed and much less anxious. But I wake up each day bracing myself for the joint pain to be worse. What is the timescale for pain potentially increasing if the MTX was in fact doing a decent job? What's the half-life of it being in my system when it took 8 weeks to kick in?
My appointment as usual was so brief I didn't get to ask all these questions, so any experience you can share would be very welcome.