I take 2.5 mg , 8 pills every Saturday. By 3pm i'm feeling brain fog. I take one pill every 2 hours. From 6am - 8pm. Sundays I feel tired and sleepy. I've hard RA for almost a year. At first the pain was so severe it hurt my shoulders to touch the bed. I didn't know what was wrong. Knuckles, hands were swollen. Pain throughout my body. Very scary. Prednisone helped until I could see a Rheumatologist. Methotrexate has been a miracle drug. I know longer require help buttoning or zipping my clothes. My RA started at the top of the chart and almost overnight. RA went to my father's lungs and killed him.