I took my second dose of Methotrexate on Saturday morning 10mg, I felt a little nauseous on Saturday evening but by 5 am Sunday morning I honestly thought I was dying, the pain I my stomach was agony, I then developed such a high temperature and sweating profusely my husband was having to keep cooling me with cold compress, my entire body was writhing in pain from the inside out. I also had horrendous diarrhoea this lasted about 5 hours at one point my husband was going to ring an ambulance I was so out of it. Today I feel like I have been through the mangle, I have never been so ill in my life and each time I have tried to eat I get an attack of cramps. Is this going to happen each weekend after taking them or will my body begin to tolerate it better. I am so worried as I up my dose next week. I tried to call the helpline today but it is not open until the morning. I know I don't tolerate NSAIDS these really upset my tummy but nothing like what I went through yesterday.I am 50 year old have Fibromyalgia and seronegative rheumatoid arthritis. Things have been pretty hellish lately, I really don't think I can take much more.