NRAS

33,718 members • 41,787 posts

Methotrexate tablets and side effects?

Am only on my 5th week of MTX tablets. I have been noticing that, in addition to the general feeling of yuckiness after taking them, I am now also feeling quite rough from the 2nd day after taking through to usually the 5th, with a general ‘cold like’ feeling with a mild burning throat and nose.

I'm guessing this is just a side effect and nothing to worry about, as it does seem to happen each time but eases up again, but thought I'd ask if others get this too?

I, stupidly, forgot to ask at my appointment last week even though I'd written down a list of things to ask! I did mention it to the nurse who takes the blood test and she didn't seem concerned, but said you must call immediately if you get any infection, especially a sore throat, and to stop the MTX.

Being new to it all, I am just not sure when or if to think something is worth mentioning to the Gp and don't want to turn into, or be thought of as, a hypochondriac!

Written by

Niao

To view profiles and participate in discussions please or .

Read more about...

37 Replies

•

Hi Niao. You should always approach your doctor if you have any questions or worries, don’t let it fester. Personally, I feel extra fatigued and weak the day after MTX and a bit more fatigued than usual the following day. What time of day do you take the tablets? I inject at night to help me sleep off the initial side effects which definitely helps.

Thank you.

I take mine first thing in the morning. I was so happy not to have had any nausea, which was my main concern, that I've just been accepting the rest of it! Did ask the nurse but as I said she didn't seem concerned. I'm just not too sure what constitutes a sore throat in their eyes?

I had most of the side effects but not anything like what you mentioned here. Most of the side effects were gone after about a year of Mtx. Nauseas, vomiting and cool stomach were also gone when Mtx dosage has been reduced to 7.5 mg.

Suggest you check with your rheumy.

Thank you. I feel very lucky not to have had much nausea, at least not yet!

I think I'll give the nurse a ring on Monday, just to be sure, but I hadn't been worrying too much as the nurse taking the bloods wasn't concerned.

I ,as said, very stupidly, went in armed with questions to ask but came home realising I hadn't asked that one!

I think it is quite normal as when we see our rheumy, most of the questions go missing from our mind. So I always write them down and bring with me a long list to ask. I make sure I keep the list in my hand. Now I use my phone to note down the questions and always have my phone in hand with me when I talk to my rheumy.

Thank you. Yep, I do the same and did this time but still failed to ask the question! There were just too many things to cover and I got sidetracked. Turns out I have an infection so have had to stop the methotrexate until I get better.

All the best and Season's Greetings and Healthy Happy New Year to you. X

Hi Niao. I've been on injections since September last year and always feel rough for the first few days after but I don't get a sore throat (yet 😟). I think you're wise to give the rheumy nurse a ring just to check it out. xx

Thankyou springcross, think I will. Can't believe I was so stupid as to forget to ask at last week's appointment! I asked about intestinal/stomach side effects but totally forgot this, even with it written on my list!

I do that too so you're not alone. xx

🙂🙃

Hi Niao, I do sometimes get a bit of a sore throat the day after taking my methotrexate tablets, but it doesn’t feel as sore as a proper sore throat if that makes sense, more an irritation. I did mention it to Rheumy nurse at start of being on methotrexate, and she told me that as long as my blood results were coming back ok, they weren’t too concerned. Now if I get it I tend to just up my fluids that day. I haven’t had a burning nose feeling though, and with everything else going on right now, I would agree with others that it’s probably best to raise it to be on the safe side. Take care xx

Thank you. Yes, I hadn't been overly worried as it is really more like a just being run down feeling. My bloods have all been fine too. It's just so difficult as I have always been prone to sore throats and sinus trouble and my throat would often be red/inflamed looking with swollen glands ( think to do with Fibromyalgia) so I don't know how I'm going to be able to tell the difference and worry I'll never be off the phone to the Gp at this rate!

I think in the early days they expect you to be in contact more often anyway, better safe than sorry xx

🙂

Are you taking folic acid...that helps with the yucky feeling..speak to your rheumy nurse.

Yes, but just the 5mg days after, so may ask about upping the dose, or taking on 6 days. Thank you.

Definitely ask about that.... I took a 5mg FA tab six days a week for 7 years and the only side effect I had was a slight metallic taste in my mouth and a Mint Imperial soon fixed that.

Yes, thank you, I think I will. I meant to say I do actually take extra folates in my multi B on another 5 days but realise that the dosage in these is very small by contrast . I will remember the Mint imperial!!🙂

I haven’t had the side effects you mention, just feel a little more tired the day after now I am the injection form.

I had my folic acid increased to six a day and alongside moving over to the injections I now only have a couple of days at the most of feeling more fatigued. I also do my injection after having my evening meal so sleep off most of the side effects.

I tend to prone to having swollen glands and a bit of sore throat but nothing to write home about so to speak. Maybe a chat with your rheumy nurse to ask what kind of sore throat is a concern and maybe to ask to increase your folic acid to 6 days a week. It made a big difference to me. x

Thank you. Yes, good advice. I did raise the matter of maybe trying the injection, but for the intestinal issues I'm having. He wants me to persevere with the tablets a while longer, and I'm also to start Hydroxychloriquine, so no I'll maybe have more questions and side effects!!

Hi NiaoMy early side effects were helped by a change in how I take the Folic acid. My Rheumy changed that from one dose the day after MTX to a smaller dose but taken every day except the MTX day. Did help but the biggest help was weeks later changing to injections. I was very worried about them but they are easy and painfree. Still get a rubbish day the day after MTX but all other side effects have almost gone away. Good luck with the conversation with your rheumy.

Thank you! Yes, I feel a daily dose may be better. I did raise the possibility of changing to injections but he said, not yet! But it helps a lot to hear that you find them easy and pain-free as I will ask again if I feel things are not settling, and, being a wimp, I was a bit worried about them!🙂

hello, I also used to feel rubbish like you do. I changed from the tablets to the pen injection and dont have the problems now! worth mentioning to your specialist next time. have a good day.

oops ...have just seen you already did mention it! And no not painful, should you be allowed!

Thank you!I have just been onto the rheumy nurse, wish I hadn't bothered. She clearly wished I hadn't bothered her by her tone and just said, can't help you with that, need to speak to GP etc. Feeling a but despondent but that'll teach me not to forget to ask everything at the Rheumatology appointment!

ooooo not good, RA nurses have been amazing where I am.Naughty cos that's their job

Is there only one RA nurse ?

Hopefully just an off day, but she's had a few of those! I think there are a couple so maybe better luck next time!🙂

Try to find out the name of the more favourable nurse then you can ask for her in future.

Will do. 🙂🙂

Ah yes sounds familiar I was the same sometimes feels fluey.

In the end I was swapped to injections by passing the stomach helped a bit with yuckness.

Think they like to see how well tolerate MTX.

I'm afraid generally feel off couple of days after taken it, but flare ups ensure I keep with it.

That said always worth a chat with your RA nurse as well as consultant, nurses often know things about coping with the whole RA condition.

Does get easier longer you use it I find, but deffo rock & hard place scenario.

Hang in

Thank you. Yep, will persevere for another little while on the tablets but if still bad, will ask about injection. It is a kind of mild fluey feel.

Yes that is how I feel some weeks too

Unfortunately, this time at least, I think it is a viral infection, hopefully just a cold and the the dreaded other one!!! Have had to stop MTX till I'm better. Merry Christmas Happy5 ,and a Healthy Happy Peaceful New Year! x

Been on methotrexate for nearly five years used to feel a bit nauseous a day or two after but now feel sick most of the time , been taking it for nail psoriasis am on 15mg folic acid does ease the sickly feeling but cannot bear feeling sick for three/four days so am going to see if I can take something else

Oh dear, I too would see about something else in your case. I feel so lucky to not have had the nausea so far, long may that be the case please! It must be horrible! Really hope you find a solution. x

Methotrexate can make you very dehydrated so drinking plenty might help. I used to take my tablets in the morning with a pint of water and then drink as much as I could throughout that day

Good advice, thank you. Am thinking now it may not be side effects as have had to come off for a week due to virus, hopefully not 'the' virus, more likely a cold, but will see!

NRAS

Home

About

Posts

Members

Methotrexate tablets and side effects?

You may also like...

methotrexate delayed side effects?

Methotrexate, side effects & work

Methotrexate - worsening side-effects

Methotrexate side effects

Side effects from methotrexate

Related Posts

Moderation team

Popular Posts

Methotrexate tablets and side effects?: Am only on my... - NRAS

NRAS

Not what you're looking for?

You may also like...

Related Posts

Moderation team

Popular Posts